Next Article in Journal
Pathogenesis of Lafora Disease: Transition of Soluble Glycogen to Insoluble Polyglucosan
Next Article in Special Issue
Translational Implication of Galectin-9 in the Pathogenesis and Treatment of Viral Infection
Previous Article in Journal
Treatment of the First Acute Relapse Following Therapeutic Plasma Exchange in Formerly Glucocorticosteroid-Unresponsive Multiple Sclerosis Patients—A Multicenter Study to Evaluate Glucocorticosteroid Responsiveness
Previous Article in Special Issue
Galectins-1, -3, and -7 Are Prognostic Markers for Survival of Ovarian Cancer Patients
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 18
Issue 8
10.3390/ijms18081756
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

Galectin-3 Performance in Histologic and Cytologic Assessment of Thyroid Nodules: A Systematic Review and Meta-Analysis

by
Pierpaolo Trimboli
1,*,
Camilla Virili
2,
Francesco Romanelli
3,
Anna Crescenzi
4 and
Luca Giovanella
1
1
Department of Nuclear Medicine and Thyroid Centre, Oncology Institute of Southern Switzerland, Via Ospedale, 6500 Bellinzona, Switzerland
2
Department of Medico-surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy
3
Department of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy
4
Pathology Unit, University Hospital Campus Bio Medico, 00128 Rome, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2017, 18(8), 1756; https://doi.org/10.3390/ijms18081756
Submission received: 15 July 2017 / Revised: 8 August 2017 / Accepted: 10 August 2017 / Published: 11 August 2017
(This article belongs to the Special Issue Galectins in Cancer and Translational Medicine)
Browse Figures
Versions Notes

Abstract

The literature on Galectin-3 (Gal-3) was systematically reviewed to achieve more robust information on its histologic reliability in identifying thyroid cancers and on the concordance between Gal-3 test in histologic and cytologic samples. A computer search of the PubMed and Scopus databases was conducted by combinations of the terms thyroid and Gal-3. Initially, 545 articles were found and, after their critical review, 52 original papers were finally included. They reported 8172 nodules with histologic evaluation of Gal-3, of which 358 with also preoperative FNAC Gal-3 assessment. At histology, Gal-3 sensitivity was 87% (95% confidence intervals [CI] from 86% to 88%), and specificity 87% (95% CI from 86% to 88%); in both cases, we found heterogeneity (I2 85% and 93%, respectively) and significant publication bias (p < 0.001). The pooled rate of positive Gal-3 at fine needle aspiration (FNAC) among cancers with histologically proven Gal-3 positivity was 94% (95% CI from 89% to 97%), with neither heterogeneity (I2 14.5%) nor bias (p = 0.086). These data show high reliability of Gal-3 for thyroid cancer at histology, while its sensitivity on FNAC samples is lower. The limits of cytologic preparations and interpretation of Gal-3 results have to be solved.
Keywords: thyroid cancer; meta-analysis; cytology; Galectin-3; fine needle aspiration (FNAC) thyroid cancer; meta-analysis; cytology; Galectin-3; fine needle aspiration (FNAC)
Graphical Abstract

Share and Cite

MDPI and ACS Style

Trimboli, P.; Virili, C.; Romanelli, F.; Crescenzi, A.; Giovanella, L. Galectin-3 Performance in Histologic and Cytologic Assessment of Thyroid Nodules: A Systematic Review and Meta-Analysis. Int. J. Mol. Sci. 2017, 18, 1756. https://doi.org/10.3390/ijms18081756

AMA Style

Trimboli P, Virili C, Romanelli F, Crescenzi A, Giovanella L. Galectin-3 Performance in Histologic and Cytologic Assessment of Thyroid Nodules: A Systematic Review and Meta-Analysis. International Journal of Molecular Sciences. 2017; 18(8):1756. https://doi.org/10.3390/ijms18081756

Chicago/Turabian Style

Trimboli, Pierpaolo, Camilla Virili, Francesco Romanelli, Anna Crescenzi, and Luca Giovanella. 2017. "Galectin-3 Performance in Histologic and Cytologic Assessment of Thyroid Nodules: A Systematic Review and Meta-Analysis" International Journal of Molecular Sciences 18, no. 8: 1756. https://doi.org/10.3390/ijms18081756

APA Style

Trimboli, P., Virili, C., Romanelli, F., Crescenzi, A., & Giovanella, L. (2017). Galectin-3 Performance in Histologic and Cytologic Assessment of Thyroid Nodules: A Systematic Review and Meta-Analysis. International Journal of Molecular Sciences, 18(8), 1756. https://doi.org/10.3390/ijms18081756

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop