Next Article in Journal
The Effects of Selective Hematopoietic Expression of Human IL-37 on Systemic Inflammation and Atherosclerosis in LDLr-Deficient Mice
Next Article in Special Issue
Microtubule Depolymerization by Kinase Inhibitors: Unexpected Findings of Dual Inhibitors
Previous Article in Journal
Comparative Studies on Behavioral, Cognitive and Biomolecular Profiling of ICR, C57BL/6 and Its Sub-Strains Suitable for Scopolamine-Induced Amnesic Models
Previous Article in Special Issue
Modeling the Colchicum autumnale Tubulin and a Comparison of Its Interaction with Colchicine to Human Tubulin
Review

Taxol®: The First Microtubule Stabilizing Agent

1
Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
2
Department of Obstetrics and Gynecology and Women’s Health, Division of Gynecologic Oncology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2017, 18(8), 1733; https://doi.org/10.3390/ijms18081733
Received: 20 June 2017 / Revised: 27 July 2017 / Accepted: 28 July 2017 / Published: 9 August 2017
(This article belongs to the Special Issue Microtubule-Targeting Agents)
Taxol®, an antitumor drug with significant activity, is the first microtubule stabilizing agent described in the literature. This short review of the mechanism of action of Taxol® emphasizes the research done in the Horwitz’ laboratory. It discusses the contribution of photoaffinity labeled analogues of Taxol® toward our understanding of the binding site of the drug on the microtubule. The importance of hydrogen/deuterium exchange experiments to further our insights into the stabilization of microtubules by Taxol® is addressed. The development of drug resistance, a major problem that arises in the clinic, is discussed. Studies describing differential drug binding to distinct β-tubulin isotypes are presented. Looking forward, it is suggested that the β-tubulin isotype content of a tumor may influence its responses to Taxol®. View Full-Text
Keywords: Taxol®; drug binding site; photoaffinity labeling; drug resistance; tubulin isotypes Taxol®; drug binding site; photoaffinity labeling; drug resistance; tubulin isotypes
Show Figures

Figure 1

MDPI and ACS Style

Yang, C.-P.H.; Horwitz, S.B. Taxol®: The First Microtubule Stabilizing Agent. Int. J. Mol. Sci. 2017, 18, 1733. https://doi.org/10.3390/ijms18081733

AMA Style

Yang C-PH, Horwitz SB. Taxol®: The First Microtubule Stabilizing Agent. International Journal of Molecular Sciences. 2017; 18(8):1733. https://doi.org/10.3390/ijms18081733

Chicago/Turabian Style

Yang, Chia-Ping H., and Susan B. Horwitz 2017. "Taxol®: The First Microtubule Stabilizing Agent" International Journal of Molecular Sciences 18, no. 8: 1733. https://doi.org/10.3390/ijms18081733

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop