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Int. J. Mol. Sci. 2017, 18(12), 2508; https://doi.org/10.3390/ijms18122508

Microtubule Depolymerization by Kinase Inhibitors: Unexpected Findings of Dual Inhibitors

Medical Research Institute, Tokyo Women’s Medical University, Tokyo 162-8666, Japan
Received: 30 October 2017 / Revised: 20 November 2017 / Accepted: 21 November 2017 / Published: 23 November 2017
(This article belongs to the Special Issue Microtubule-Targeting Agents)
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Abstract

Microtubule-targeting agents are widely used as clinical drugs in the treatment of cancer. However, some kinase inhibitors can also disrupt microtubule organization by directly binding to tubulin. These unexpected effects may result in a plethora of harmful events and/or a misinterpretation of the experimental results. Thus, further studies are needed to understand these dual inhibitors. In this review, I discuss the roles of dual inhibitors of kinase activity and microtubule function as well as describe the properties underlining their dual roles. Since both kinase and microtubule inhibitors cause cell toxicity and cell cycle arrest, it is difficult to determine which inhibitor is responsible for each phenotype. A discrimination of cell cycle arrest at G0/G1 or G2/M and/or image analyses of cellular phenotype may eventually lead to new insights on drug duality. Because of the indispensable roles of microtubules in mitosis and vesicle transport, I propose a simple and easy method to identify microtubule depolymerizing compounds. View Full-Text
Keywords: microtubules; kinase inhibitor; dual inhibitor; mitotic arrest; intracellular traffic microtubules; kinase inhibitor; dual inhibitor; mitotic arrest; intracellular traffic
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Tanabe, K. Microtubule Depolymerization by Kinase Inhibitors: Unexpected Findings of Dual Inhibitors. Int. J. Mol. Sci. 2017, 18, 2508.

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