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Tenebrio molitor Larvae Inhibit Adipogenesis through AMPK and MAPKs Signaling in 3T3-L1 Adipocytes and Obesity in High-Fat Diet-Induced Obese Mice

1
Department of Agricultural Biology, National Institute of Agricultural Sciences, RDA, Wanju-gun 55365, Korea
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Department of Biochemistry, School of Medicine, Dongguk University, Gyeongju 780-714, Korea
3
Graduate School of Integrated Bioindustry, Sejong University, Seoul 05006, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Charles Brennan
Int. J. Mol. Sci. 2017, 18(3), 518; https://doi.org/10.3390/ijms18030518
Received: 19 December 2016 / Revised: 6 February 2017 / Accepted: 15 February 2017 / Published: 28 February 2017
(This article belongs to the Section Bioactives and Nutraceuticals)
Despite the increasing interest in insect-based bioactive products, the biological activities of these products are rarely studied adequately. Larvae of Tenebrio molitor, the yellow mealworm, have been eaten as a traditional food and provide many health benefits. Therefore, we hypothesized that T. molitor larvae might influence adipogenesis and obesity-related disorders. In the present study, we investigated the anti-adipogenic and antiobesity effects of T. molitor larvae in vitro and in vivo. The lipid accumulation and triglyceride content in mature adipocytes was reduced significantly (up to 90%) upon exposure to an ethanol extract of T. molitor larvae, without a reduction in cell viability. Exposure also resulted in key adipogenic and lipogenic transcription factors. Additionally, in adipogenic differentiation medium the extract induced phosphorylation of adenosine monophosphate (AMP)-activated protein kinase and mitogen-activated protein kinases. Daily oral administration of T. molitor larvae powder to obese mice fed high-fat diet attenuated body weight gain. We also found that the powder efficiently reduced hepatic steatosis as well as aspartate and alanine transaminase enzyme levels in mice fed a high-fat diet. Our results suggest that T. molitor larvae extract has an antiobesity effect when administered as a food supplement and has potential as a therapeutic agent for obesity. View Full-Text
Keywords: Tenebrio molitor larvae; diet-induced obesity; 3T3-L1; adipogenesis; hepatic steatosis Tenebrio molitor larvae; diet-induced obesity; 3T3-L1; adipogenesis; hepatic steatosis
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Seo, M.; Goo, T.-W.; Chung, M.Y.; Baek, M.; Hwang, J.-S.; Kim, M.-A.; Yun, E.-Y. Tenebrio molitor Larvae Inhibit Adipogenesis through AMPK and MAPKs Signaling in 3T3-L1 Adipocytes and Obesity in High-Fat Diet-Induced Obese Mice. Int. J. Mol. Sci. 2017, 18, 518.

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