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Open AccessDiscussion

Pan-Domain Analysis of ZIP Zinc Transporters

1
Aberdeen Fungal Group, Medical Research Council Centre for Medical Mycology, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK
2
School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2017, 18(12), 2631; https://doi.org/10.3390/ijms18122631
Received: 9 November 2017 / Revised: 1 December 2017 / Accepted: 1 December 2017 / Published: 6 December 2017
(This article belongs to the Special Issue Zinc Signaling in Physiology and Pathogenesis)
The ZIP (Zrt/Irt-like protein) family of zinc transporters is found in all three domains of life. However, little is known about the phylogenetic relationship amongst ZIP transporters, their distribution, or their origin. Here we employed phylogenetic analysis to explore the evolution of ZIP transporters, with a focus on the major human fungal pathogen, Candida albicans. Pan-domain analysis of bacterial, archaeal, fungal, and human proteins revealed a complex relationship amongst the ZIP family members. Here we report (i) a eukaryote-wide group of cellular zinc importers, (ii) a fungal-specific group of zinc importers having genetic association with the fungal zincophore, and, (iii) a pan-kingdom supercluster made up of two distinct subgroups with orthologues in bacterial, archaeal, and eukaryotic phyla. View Full-Text
Keywords: ZIP; zinc; transport; transporter; evolution; pathogenic fungi; Candida albicans ZIP; zinc; transport; transporter; evolution; pathogenic fungi; Candida albicans
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MDPI and ACS Style

Lehtovirta-Morley, L.E.; Alsarraf, M.; Wilson, D. Pan-Domain Analysis of ZIP Zinc Transporters. Int. J. Mol. Sci. 2017, 18, 2631.

AMA Style

Lehtovirta-Morley LE, Alsarraf M, Wilson D. Pan-Domain Analysis of ZIP Zinc Transporters. International Journal of Molecular Sciences. 2017; 18(12):2631.

Chicago/Turabian Style

Lehtovirta-Morley, Laura E.; Alsarraf, Mohammad; Wilson, Duncan. 2017. "Pan-Domain Analysis of ZIP Zinc Transporters" Int. J. Mol. Sci. 18, no. 12: 2631.

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