Infectious Bronchitis Virus Variants: Molecular Analysis and Pathogenicity Investigation
1
Department of Veterinary Medicine, National Taiwan University, Taipei 10617, Taiwan
2
Research Center for Nanotechnology and Infectious Diseases, Taipei 11529, Taiwan
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2017, 18(10), 2030; https://doi.org/10.3390/ijms18102030
Received: 12 August 2017
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Revised: 16 September 2017
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Accepted: 18 September 2017
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Published: 22 September 2017
(This article belongs to the Special Issue Molecular Research of Emerging Viruses: Viral Evolution, Diagnostics and Pathogenesis and Therapeutics)
Infectious bronchitis virus (IBV) variants constantly emerge and pose economic threats to poultry farms worldwide. Numerous studies on the molecular and pathogenic characterization of IBV variants have been performed between 2007 and 2017, which we have reviewed herein. We noted that viral genetic mutations and recombination events commonly gave rise to distinct IBV genotypes, serotypes and pathotypes. In addition to characterizing the S1 genes, full viral genomic sequencing, comprehensive antigenicity, and pathogenicity studies on emerging variants have advanced our understanding of IBV infections, which is valuable for developing countermeasures against IBV field outbreaks. This review of IBV variants provides practical value for understanding their phylogenetic relationships and epidemiology from both regional and worldwide viewpoints.
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Keywords:
infectious bronchitis virus; variants; genotypes; antigenicity; pathogenicity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
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MDPI and ACS Style
Lin, S.-Y.; Chen, H.-W. Infectious Bronchitis Virus Variants: Molecular Analysis and Pathogenicity Investigation. Int. J. Mol. Sci. 2017, 18, 2030. https://doi.org/10.3390/ijms18102030
AMA Style
Lin S-Y, Chen H-W. Infectious Bronchitis Virus Variants: Molecular Analysis and Pathogenicity Investigation. International Journal of Molecular Sciences. 2017; 18(10):2030. https://doi.org/10.3390/ijms18102030
Chicago/Turabian StyleLin, Shu-Yi, and Hui-Wen Chen. 2017. "Infectious Bronchitis Virus Variants: Molecular Analysis and Pathogenicity Investigation" International Journal of Molecular Sciences 18, no. 10: 2030. https://doi.org/10.3390/ijms18102030
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