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Microcephaly Prevalence in Infants Born to Zika Virus-Infected Women: A Systematic Review and Meta-Analysis

1
Department of Genetics, Federal University of Pernambuco, Avenida da Engenharia, Cidade Universitária, Recife 50740-600, Brazil
2
Institute for Maternal and Child Health, Scientific Institute for Research, Hospitalization and Care (IRCCS) Burlo Garofolo, 34137 Trieste, Italy
3
Department of Developmental and Reproductive Sciences, Genetic Unit, University of Trieste, 34127 Trieste, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2017, 18(8), 1714; https://doi.org/10.3390/ijms18081714
Received: 13 June 2017 / Revised: 31 July 2017 / Accepted: 3 August 2017 / Published: 5 August 2017
Zika virus is an emergent flavivirus transmitted by Aedes genus mosquitoes that recently reached the Americas and was soon implicated in an increase of microcephaly incidence. The objective of the present study is to systematically review the published data and perform a meta-analysis to estimate the prevalence of microcephaly in babies born to Zika virus-infected women during pregnancy. We searched PubMed and Cochrane databases, included cohort studies, and excluded case reports and case series publications. We extracted sample sizes and the number of microcephaly cases from eight studies, which permitted a calculation of prevalence rates that are pooled in a random-effects model meta-analysis. We estimated the prevalence of microcephaly of 2.3% (95% CI = 1.0–5.3%) among all pregnancies. Limitations include mixed samples of women infected at different pregnancy times, since it is known that infection at the first trimester is associated with higher risk to congenital anomalies. The estimates are deceptively low, given the devastating impact the infection causes over children and their families. We hope our study contributes to public health knowledge to fight Zika virus epidemics to protect mothers and their newborns. View Full-Text
Keywords: flavivirus; arbovirus; congenital Zika virus syndrome; microcephaly; emergent diseases flavivirus; arbovirus; congenital Zika virus syndrome; microcephaly; emergent diseases
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Coelho, A.V.C.; Crovella, S. Microcephaly Prevalence in Infants Born to Zika Virus-Infected Women: A Systematic Review and Meta-Analysis. Int. J. Mol. Sci. 2017, 18, 1714.

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