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Article

The Effect of MCP-1/CCR2 on the Proliferation and Senescence of Epidermal Constituent Cells in Solar Lentigo

by
Woo Jin Lee
†,
Soo Youn Jo
†,
Mi Hye Lee
,
Chong Hyun Won
,
Mi Woo Lee
,
Jee Ho Choi
and
Sung Eun Chang
*
Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Korea
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2016, 17(6), 948; https://doi.org/10.3390/ijms17060948
Submission received: 1 April 2016 / Revised: 7 June 2016 / Accepted: 8 June 2016 / Published: 15 June 2016
(This article belongs to the Section Biochemistry)
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Abstract

Solar lentigo (SL) is a representative photoaging skin disorder. Alteration of the main epidermal constituent cells—keratinocytes and melanocytes—in relation to the photoaged dermal environment or chemokine/cytokine network is suggested as its pathogenesis. Among these, we focused on monocyte chemoattractant protein-1 (MCP-1), as it is known to be associated with tissue aging. For the first time, we report that the MCP-1 receptor, CCR2, is expressed in normal human melanocytes. In SL tissue, there was an increase of CCR2+Melan A+ melanocytes with positivity to Rb protein compared to peri-lesional normal skin. MCP-1 induced the proliferation of normal human melanocytes without a significant change in the melanin content. MCP-1 treatment in normal human keratinocytes showed an increase in senescence-associated β-galactosidase staining and p53 and p21 protein expressions. In summary, MCP-1 may participate in the development of SL by affecting epidermal constituent cells, for example, by inducing melanocyte proliferation and keratinocyte senescence.
Keywords: solar lentigo; monocyte chemoattractant protein-1; epidermal constituent cells solar lentigo; monocyte chemoattractant protein-1; epidermal constituent cells

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MDPI and ACS Style

Lee, W.J.; Jo, S.Y.; Lee, M.H.; Won, C.H.; Lee, M.W.; Choi, J.H.; Chang, S.E. The Effect of MCP-1/CCR2 on the Proliferation and Senescence of Epidermal Constituent Cells in Solar Lentigo. Int. J. Mol. Sci. 2016, 17, 948. https://doi.org/10.3390/ijms17060948

AMA Style

Lee WJ, Jo SY, Lee MH, Won CH, Lee MW, Choi JH, Chang SE. The Effect of MCP-1/CCR2 on the Proliferation and Senescence of Epidermal Constituent Cells in Solar Lentigo. International Journal of Molecular Sciences. 2016; 17(6):948. https://doi.org/10.3390/ijms17060948

Chicago/Turabian Style

Lee, Woo Jin, Soo Youn Jo, Mi Hye Lee, Chong Hyun Won, Mi Woo Lee, Jee Ho Choi, and Sung Eun Chang. 2016. "The Effect of MCP-1/CCR2 on the Proliferation and Senescence of Epidermal Constituent Cells in Solar Lentigo" International Journal of Molecular Sciences 17, no. 6: 948. https://doi.org/10.3390/ijms17060948

APA Style

Lee, W. J., Jo, S. Y., Lee, M. H., Won, C. H., Lee, M. W., Choi, J. H., & Chang, S. E. (2016). The Effect of MCP-1/CCR2 on the Proliferation and Senescence of Epidermal Constituent Cells in Solar Lentigo. International Journal of Molecular Sciences, 17(6), 948. https://doi.org/10.3390/ijms17060948

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