Next Article in Journal
MT1-MMP Inhibits the Activity of Bst-2 via Their Cytoplasmic Domains Dependent Interaction
Next Article in Special Issue
Signaling Pathways in Melanogenesis
Previous Article in Journal
The miRacle in Pancreatic Cancer by miRNAs: Tiny Angels or Devils in Disease Progression
Previous Article in Special Issue
“Fifty Shades” of Black and Red or How Carboxyl Groups Fine Tune Eumelanin and Pheomelanin Properties
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 17
Issue 6
10.3390/ijms17060824
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

Heterogeneous Pathology of Melasma and Its Clinical Implications

by
Soon-Hyo Kwon
1,2,
Young-Ji Hwang
1,2,
Soo-Keun Lee
1,2 and
Kyoung-Chan Park
1,2,*
1
College of Medicine, Seoul National University, Jongro-gu, Seoul 03080, Korea
2
Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do 13620, Korea
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2016, 17(6), 824; https://doi.org/10.3390/ijms17060824
Submission received: 8 March 2016 / Revised: 14 May 2016 / Accepted: 23 May 2016 / Published: 26 May 2016
(This article belongs to the Special Issue Biochemistry and Mechanisms of Melanogenesis)
Browse Figures
Versions Notes

Abstract

Melasma is a commonly acquired hypermelanosis that affects sun-exposed areas of the skin, with frequent facial involvement. Its histologic manifestations are evident in the epidermis, extracellular matrix, and dermis. In addition to epidermal pigmentation, pathologic findings of melasma include extracellular matrix abnormality, especially solar elastosis. The disrupted basement membrane has been described in melasma with variable incidences. In the dermis, an increase in vascularity and an increase in the number of mast cells were observed, indicating that dermal factors have critical roles in the pathogenesis of melasma, despite the fact that melasma is characterized by epidermal hyperpigmentation. This review discusses such histologic characteristics of melasma, with consideration to their implications for melasma treatment.
Keywords: basement membrane; histopathology; mast cells; melasma; photoaging; vascularization basement membrane; histopathology; mast cells; melasma; photoaging; vascularization
Graphical Abstract

Share and Cite

MDPI and ACS Style

Kwon, S.-H.; Hwang, Y.-J.; Lee, S.-K.; Park, K.-C. Heterogeneous Pathology of Melasma and Its Clinical Implications. Int. J. Mol. Sci. 2016, 17, 824. https://doi.org/10.3390/ijms17060824

AMA Style

Kwon S-H, Hwang Y-J, Lee S-K, Park K-C. Heterogeneous Pathology of Melasma and Its Clinical Implications. International Journal of Molecular Sciences. 2016; 17(6):824. https://doi.org/10.3390/ijms17060824

Chicago/Turabian Style

Kwon, Soon-Hyo, Young-Ji Hwang, Soo-Keun Lee, and Kyoung-Chan Park. 2016. "Heterogeneous Pathology of Melasma and Its Clinical Implications" International Journal of Molecular Sciences 17, no. 6: 824. https://doi.org/10.3390/ijms17060824

APA Style

Kwon, S.-H., Hwang, Y.-J., Lee, S.-K., & Park, K.-C. (2016). Heterogeneous Pathology of Melasma and Its Clinical Implications. International Journal of Molecular Sciences, 17(6), 824. https://doi.org/10.3390/ijms17060824

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop