Influence of Long-Distance Bicycle Riding on Serum/Urinary Biomarkers of Prostate Cancer
AbstractHerein, we present a study focused on the determination of the influence of long-distance (53 km) bicycle riding on levels of chosen biochemical urinary and serum prostate cancer (PCa) biomarkers total prostate-specific antigen (tPSA), free PSA (fPSA) and sarcosine. Fourteen healthy participants with no evidence of prostate diseases, in the age range from 49–57 years with a median of 52 years, underwent physical exercise (mean race time of 150 ± 20 min, elevation increase of 472 m) and pre- and post-ride blood/urine sampling. It was found that bicycle riding resulted in elevated serum uric acid (p = 0.001, median 271.76 vs. 308.44 µmol/L pre- and post-ride, respectively), lactate (p = 0.01, median 2.98 vs. 4.8 mmol/L) and C-reactive protein (p = 0.01, 0.0–0.01 mg/L). It is noteworthy that our work supports the studies demonstrating an increased PSA after mechanical manipulation of the prostate. The subjects exhibited either significantly higher post-ride tPSA (p = 0.002, median 0.69 vs. 1.1 ng/mL pre- and post-ride, respectively) and fPSA (p = 0.028, median 0.25 vs. 0.35 ng/mL). Contrary to that, sarcosine levels were not significantly affected by physical exercise (p = 0.20, median 1.64 vs. 1.92 µmol/mL for serum sarcosine, and p = 0.15, median 0.02 µmol/mmol of creatinine vs. 0.01 µmol/mmol of creatinine for urinary sarcosine). Taken together, our pilot study provides the first evidence that the potential biomarker of PCa—sarcosine does not have a drawback by means of a bicycle riding-induced false positivity, as was shown in the case of PSA. View Full-Text
Share & Cite This Article
Heger, Z.; Gumulec, J.; Ondrak, A.; Skoda, J.; Zitka, Z.; Cernei, N.; Masarik, M.; Zitka, O.; Adam, V. Influence of Long-Distance Bicycle Riding on Serum/Urinary Biomarkers of Prostate Cancer. Int. J. Mol. Sci. 2016, 17, 377.
Heger Z, Gumulec J, Ondrak A, Skoda J, Zitka Z, Cernei N, Masarik M, Zitka O, Adam V. Influence of Long-Distance Bicycle Riding on Serum/Urinary Biomarkers of Prostate Cancer. International Journal of Molecular Sciences. 2016; 17(3):377.Chicago/Turabian Style
Heger, Zbynek; Gumulec, Jaromir; Ondrak, Ales; Skoda, Jan; Zitka, Zdenek; Cernei, Natalia; Masarik, Michal; Zitka, Ondrej; Adam, Vojtech. 2016. "Influence of Long-Distance Bicycle Riding on Serum/Urinary Biomarkers of Prostate Cancer." Int. J. Mol. Sci. 17, no. 3: 377.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.