The Latin American DILI Registry Experience: A Successful Ongoing Collaborative Strategic Initiative
Abstract
:1. Introduction
2. What Were Our Goals?
3. How Was the Project Implemented, and What Have We Attained so Far?
4. Preliminary Results from Our Registry
5. Where Do We Stand Today and What Are We Planning for the Future?
6. Summary and Conclusions
Acknowledgments
Conflicts of Interest
Abbreviations
DILI | Drug induced liver injury |
LA | Latin America |
ALEH | Latin American Association for Liver Study |
CIOMS | Council for International Organizations of Medical Scientists |
RUCAM | Roussel Uclaf Causality Assessment Method |
NSAIDs | non-steroidal anti-inflammatory drugs |
GWA | genome wide association |
HDS | herbals and dietary supplements |
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Therapeutic Class | n (%) | ALF/OLT n (%) | Individual Agent |
---|---|---|---|
NSAIDs and anti-rheumatic drugs | 62 (32) | 16 (26) | Nimesulide, Piroxicam, Diclofenac, Naproxen |
Anti-infectious | 37 (19) | 11 (30) | Nitrofurantoin, Isoniazid, Trovofloxacin, Clarithromycin |
Genito-urinary system and sex hormones | 34 (18) | 14 (22) | Progesterone, Cyproterone Acetate, Flutamide |
Antineoplastic and immunomodulators | 10 (5) | 2 (3) | Imatinib, Tamoxifen |
Anticonvulsants | 7 (4) | 3 | Valproic Acid, Phenytoin |
Cardiovascular system | 6 (3) | 1 | Methyldopa |
Anti-virals | 5 (3) | 1 | Nevirapine |
Anesthetics | 5 (3) | 5 | Halothane |
Antithyroid | 5 (3) | 4 | Propylthiouracil |
Other groups | 20 | 5 | Ketoconazole, Griseofulvin, Disulfiram, Mycophenolate |
Individual Agent (n) | Latin DILI Network (LATINDILIN) Registry (n 206) | Spanish DILI Registry (n 867) * | DILIN Study (n 899) |
---|---|---|---|
Amoxicillin-clavulanate | 20 | 186 | 91 |
Diclofenac | 13 | 16 | 12 |
Nimesulide | 11 | 9 | - |
Nitrofurantoin | 11 | - | 42 |
Cyproterone acetate | 9 | 3 | - |
Ibuprofen | 7 | 22 | 1 |
RIP + INH + PIZ# | 7 | 29 | - |
Carbamazepine | 5 | 8 | 4 |
Phenytoin | 4 | 3 | 12 |
Thiamazole | 4 | 7 | 3 |
Variables | LATINDILI Registry (200) | Spanish DILI Registry (867) | p Value |
---|---|---|---|
Mean age (years) | 51 | 54 | 0.02 |
Female (%) | 59 | 49 | 0.01 |
Jaundice (%) | 67 | 68 | NS |
Fatal cases (%) | 4.6 | 4 | NS |
Hepatocellular damage (%) | 54 | 63 | 0.03 |
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Bessone, F.; Hernandez, N.; Lucena, M.I.; Andrade, R.J.; On behalf of the Latin DILI Network (LATINDILIN) and Spanish DILI Registry. The Latin American DILI Registry Experience: A Successful Ongoing Collaborative Strategic Initiative. Int. J. Mol. Sci. 2016, 17, 313. https://doi.org/10.3390/ijms17030313
Bessone F, Hernandez N, Lucena MI, Andrade RJ, On behalf of the Latin DILI Network (LATINDILIN) and Spanish DILI Registry. The Latin American DILI Registry Experience: A Successful Ongoing Collaborative Strategic Initiative. International Journal of Molecular Sciences. 2016; 17(3):313. https://doi.org/10.3390/ijms17030313
Chicago/Turabian StyleBessone, Fernando, Nelia Hernandez, M. Isabel Lucena, Raúl J. Andrade, and On behalf of the Latin DILI Network (LATINDILIN) and Spanish DILI Registry. 2016. "The Latin American DILI Registry Experience: A Successful Ongoing Collaborative Strategic Initiative" International Journal of Molecular Sciences 17, no. 3: 313. https://doi.org/10.3390/ijms17030313