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The Photoprotective Effect of S-Methylmethionine Sulfonium in Skin

Department of Dermatology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 110-746, Korea
College of Pharmacy, Yonsei University, Incheon 406-840, Korea
College of Pharmacy, Catholic University of Daegu, Gyeongbuk 712-702, Korea
Author to whom correspondence should be addressed.
Academic Editor: Terrence Piva
Int. J. Mol. Sci. 2015, 16(8), 17088-17100;
Received: 11 June 2015 / Revised: 14 July 2015 / Accepted: 23 July 2015 / Published: 28 July 2015
(This article belongs to the Section Biochemistry)
PDF [2217 KB, uploaded 28 July 2015]


S-Methylmethionine sulfonium (SMMS) was reported to have wound-healing effects; we therefore have investigated the photoprotective effect of SMMS in the present study. SMMS increased the viability of keratinocyte progenitor cells (KPCs) and human dermal fibroblasts (hDFs) following ultraviolet B (UVB) irradiation, and reduced the UVB-induced apoptosis in these cells. SMMS increased the phosphorylation of extracellular signal-regulated kinases (ERK), and the inhibitor of the mitogen-activated protein kinase pathway significantly decreased the SMMS-induced viability of KPCs and hDFs. In addition, SMMS attenuated the UVB-induced reactive oxygen species (ROS) generation in KPCs and hDFs. SMMS induced the collagen synthesis and reduced the matrix metalloproteinase-1 expression in UVB-irradiated hDFs. In animal studies, application of 5% and 10% SMMS before and after UVB-irradiation significantly decreased the UVB-induced erythema index and depletion of Langerhans cells. In summary, SMMS protects KPCs and hDFs from UVB irradiation, and reduces UVB-induced skin erythema and immune suppression. Therefore, SMMS can be used as a cosmetic raw material, and protect skin from UVB. View Full-Text
Keywords: S-methylmethionine sulfonium; UVB protection; dermal fibroblasts; keratinocyte progenitor cells; erythema S-methylmethionine sulfonium; UVB protection; dermal fibroblasts; keratinocyte progenitor cells; erythema

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Kim, W.-S.; Seo, H.-M.; Kim, W.-K.; Choi, J.-S.; Kim, I.; Sung, J.-H. The Photoprotective Effect of S-Methylmethionine Sulfonium in Skin. Int. J. Mol. Sci. 2015, 16, 17088-17100.

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