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Article

MicroRNA-302b Enhances the Sensitivity of Hepatocellular Carcinoma Cell Lines to 5-FU via Targeting Mcl-1 and DPYD

by
Donghui Cai
,
Kang He
,
Su'e Chang
,
Dongdong Tong
and
Chen Huang
*
Department of Genetics and Molecular Biology, Xi'an Jiaotong University College of Medicine, Xi'an 710061, China
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2015, 16(10), 23668-23682; https://doi.org/10.3390/ijms161023668
Submission received: 7 July 2015 / Revised: 24 August 2015 / Accepted: 1 September 2015 / Published: 6 October 2015
(This article belongs to the Special Issue MicroRNA Regulation)
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Abstract

MiR-302b is a member of miR-302-367 cluster. The miR-302-367 cluster played important roles in maintaining pluripotency in human embryonic stem cells (hESCs) and has been proved to be capable of suppressing cell growth in several types of cancer cell lines including Hepatocellular Carcinoma (HCC) Cell lines. However, the role that miR-302b plays in the 5-Fluorouracil (5-FU) sensitivity of HCC has not been known. This study showed that miR-302b could enhance the sensitivity to 5-FU in HCC cell lines and verified its two putative targeted genes responsible for its 5-FU sensitivity.
Keywords: miR-302b; 5-Fluorouracil (5-FU); sensitivity; hepatocellular carcinoma cell lines miR-302b; 5-Fluorouracil (5-FU); sensitivity; hepatocellular carcinoma cell lines
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MDPI and ACS Style

Cai, D.; He, K.; Chang, S.; Tong, D.; Huang, C. MicroRNA-302b Enhances the Sensitivity of Hepatocellular Carcinoma Cell Lines to 5-FU via Targeting Mcl-1 and DPYD. Int. J. Mol. Sci. 2015, 16, 23668-23682. https://doi.org/10.3390/ijms161023668

AMA Style

Cai D, He K, Chang S, Tong D, Huang C. MicroRNA-302b Enhances the Sensitivity of Hepatocellular Carcinoma Cell Lines to 5-FU via Targeting Mcl-1 and DPYD. International Journal of Molecular Sciences. 2015; 16(10):23668-23682. https://doi.org/10.3390/ijms161023668

Chicago/Turabian Style

Cai, Donghui, Kang He, Su'e Chang, Dongdong Tong, and Chen Huang. 2015. "MicroRNA-302b Enhances the Sensitivity of Hepatocellular Carcinoma Cell Lines to 5-FU via Targeting Mcl-1 and DPYD" International Journal of Molecular Sciences 16, no. 10: 23668-23682. https://doi.org/10.3390/ijms161023668

APA Style

Cai, D., He, K., Chang, S., Tong, D., & Huang, C. (2015). MicroRNA-302b Enhances the Sensitivity of Hepatocellular Carcinoma Cell Lines to 5-FU via Targeting Mcl-1 and DPYD. International Journal of Molecular Sciences, 16(10), 23668-23682. https://doi.org/10.3390/ijms161023668

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