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Int. J. Mol. Sci. 2014, 15(8), 13247-13266;

Synthesis and Properties of Poly(l-lactide)-b-poly (l-phenylalanine) Hybrid Copolymers

Departament d'Enginyeria Química, Universitat Politècnica de Catalunya, Av. Diagonal 647, E-08028 Barcelona, Spain
Author to whom correspondence should be addressed.
Received: 19 May 2014 / Revised: 28 June 2014 / Accepted: 14 July 2014 / Published: 29 July 2014
(This article belongs to the Special Issue Biodegradable Materials)
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Hybrid materials constituted by peptides and synthetic polymers have nowadays a great interest since they can combine the properties and functions of each constitutive block, being also possible to modify the final characteristics by using different topologies. Poly(l-lactide-b-l-phenylalanine) copolymers with various block lengths were synthesized by sequential ring-opening polymerization of l-lactide and the N-carboxyanhydride of l-phenylalanine. The resulting block copolymers were characterized by NMR spectrometry, IR spectroscopy, gel permeation chromatography, MALDI-TOF and UV-vis, revealing the successful incorporation of the polyphenylalanine (PPhe) peptide into the previously formed poly(l-lactide) (PLLA) polymer chain. X-ray diffraction and DSC data also suggested that the copolymers were phase-separated in domains containing either crystalline PLLA or PPhe phases. A peculiar thermal behavior was also found by thermogravimetric analysis when polyphenylalanine blocks were incorporated into polylactide. View Full-Text
Keywords: biodegradable polymers; block copolymers; self-assembly; polylactide; polyphenylalanine; ring-opening polymerization biodegradable polymers; block copolymers; self-assembly; polylactide; polyphenylalanine; ring-opening polymerization

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Planellas, M.; Puiggalí, J. Synthesis and Properties of Poly(l-lactide)-b-poly (l-phenylalanine) Hybrid Copolymers. Int. J. Mol. Sci. 2014, 15, 13247-13266.

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