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Autophagic Cell Death and Cancer

Department of Pathological Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan
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Int. J. Mol. Sci. 2014, 15(2), 3145-3153; https://doi.org/10.3390/ijms15023145
Received: 6 January 2014 / Revised: 10 February 2014 / Accepted: 13 February 2014 / Published: 21 February 2014
(This article belongs to the Collection Programmed Cell Death and Apoptosis)
Programmed cell death (PCD) is a crucial process required for the normal development and physiology of metazoans. The three major mechanisms that induce PCD are called type I (apoptosis), type II (autophagic cell death), and type III (necrotic cell death). Dysfunctional PCD leads to diseases such as cancer and neurodegeneration. Although apoptosis is the most common form of PCD, recent studies have provided evidence that there are other forms of cell death. One of such cell death is autophagic cell death, which occurs via the activation of autophagy. The present review summarizes recent knowledge about autophagic cell death and discusses the relationship with tumorigenesis. View Full-Text
Keywords: programmed cell death; autophagic cell death; Atg5-independent autophagy; Beclin1; tumorigenesis; c-Jun N-terminal kinase (JNK) programmed cell death; autophagic cell death; Atg5-independent autophagy; Beclin1; tumorigenesis; c-Jun N-terminal kinase (JNK)
MDPI and ACS Style

Shimizu, S.; Yoshida, T.; Tsujioka, M.; Arakawa, S. Autophagic Cell Death and Cancer. Int. J. Mol. Sci. 2014, 15, 3145-3153.

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