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Open AccessArticle

Characterization and Expression of the Gene Encoding En-MAPK1, an Intestinal Cell Kinase (ICK)-like Kinase Activated by the Autocrine Pheromone-Signaling Loop in the Polar Ciliate, Euplotes nobilii

Laboratory of Eukaryotic Microbiology and Animal Biology, Department of Environmental and Natural Sciences, University of Camerino, Camerino 62032, Italy
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Int. J. Mol. Sci. 2013, 14(4), 7457-7467; https://doi.org/10.3390/ijms14047457
Received: 15 February 2013 / Revised: 21 March 2013 / Accepted: 21 March 2013 / Published: 3 April 2013
(This article belongs to the Special Issue Signalling Molecules and Signal Transduction in Cells)
In the protozoan ciliate Euplotes, a transduction pathway resulting in a mitogenic cell growth response is activated by autocrine receptor binding of cell type-specific, water-borne signaling protein pheromones. In Euplotes raikovi, a marine species of temperate waters, this transduction pathway was previously shown to involve the phosphorylation of a nuclear protein kinase structurally similar to the intestinal-cell and male germ cell-associated kinases described in mammals. In E. nobilii, which is phylogenetically closely related to E. raikovi but inhabits Antarctic and Arctic waters, we have now characterized a gene encoding a structurally homologous kinase. The expression of this gene requires +1 translational frameshifting and a process of intron splicing for the production of the active protein, designated En-MAPK1, which contains amino acid substitutions of potential significance for cold-adaptation. View Full-Text
Keywords: protein kinase; signal transduction; gene structure and expression; translational frameshifting; polar ciliates protein kinase; signal transduction; gene structure and expression; translational frameshifting; polar ciliates
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MDPI and ACS Style

Candelori, A.; Luporini, P.; Alimenti, C.; Vallesi, A. Characterization and Expression of the Gene Encoding En-MAPK1, an Intestinal Cell Kinase (ICK)-like Kinase Activated by the Autocrine Pheromone-Signaling Loop in the Polar Ciliate, Euplotes nobilii. Int. J. Mol. Sci. 2013, 14, 7457-7467. https://doi.org/10.3390/ijms14047457

AMA Style

Candelori A, Luporini P, Alimenti C, Vallesi A. Characterization and Expression of the Gene Encoding En-MAPK1, an Intestinal Cell Kinase (ICK)-like Kinase Activated by the Autocrine Pheromone-Signaling Loop in the Polar Ciliate, Euplotes nobilii. International Journal of Molecular Sciences. 2013; 14(4):7457-7467. https://doi.org/10.3390/ijms14047457

Chicago/Turabian Style

Candelori, Annalisa; Luporini, Pierangelo; Alimenti, Claudio; Vallesi, Adriana. 2013. "Characterization and Expression of the Gene Encoding En-MAPK1, an Intestinal Cell Kinase (ICK)-like Kinase Activated by the Autocrine Pheromone-Signaling Loop in the Polar Ciliate, Euplotes nobilii" Int. J. Mol. Sci. 14, no. 4: 7457-7467. https://doi.org/10.3390/ijms14047457

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