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Review

Research Advances of Bioactive Sesquiterpenoids Isolated from Marine-Derived Aspergillus sp.

by
Lixiang Sun
1,2,†,
Huannan Wang
2,†,
Maocai Yan
2,
Chunmei Sai
2 and
Zhen Zhang
2,*
1
School of Pharmacy, Binzhou Medical University, 346 Guanhai Road, Yantai 264003, China
2
School of Pharmacy, Jining Medical University, 669 Xueyuan Road, Rizhao 276800, China
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Molecules 2022, 27(21), 7376; https://doi.org/10.3390/molecules27217376
Submission received: 8 October 2022 / Revised: 27 October 2022 / Accepted: 28 October 2022 / Published: 30 October 2022
(This article belongs to the Special Issue Natural Products Chemistry: Advances in Synthetic, Analytical and Bioactivity Studies)
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Abstract

Marine fungi Aspergillus sp. is an important source of natural active lead compounds with biological and chemical diversity, of which sesquiterpenoids are an extremely important class of bioactive secondary metabolites. In this paper, we review the sources, chemical structures, bioactivity, biosynthesis, and druggability evaluation of sesquiterpenoids discovered from marine fungi Aspergillus sp. since 2008. The Aspergillus species involved include mainly Aspergillus fumigatus, Aspergillus versicolor, Aspergillus flavus, Aspergillus ustus, Aspergillus sydowii, and so on, which originate from sponges, marine sediments, algae, mangroves, and corals. In recent years, 268 sesquiterpenoids were isolated from secondary metabolites of marine Aspergillus sp., 131 of which displayed bioactivities such as antitumor, antimicrobial, anti-inflammatory, and enzyme inhibitory activity. Furthermore, the main types of active sesquiterpenoids are bisabolanes, followed by drimanes, nitrobenzoyl, etc. Therefore, these novel sesquiterpenoids will provide a large number of potential lead compounds for the development of marine drugs.
Keywords: marine fungi; sesquiterpenoids; Aspergillus; bioactivity marine fungi; sesquiterpenoids; Aspergillus; bioactivity

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MDPI and ACS Style

Sun, L.; Wang, H.; Yan, M.; Sai, C.; Zhang, Z. Research Advances of Bioactive Sesquiterpenoids Isolated from Marine-Derived Aspergillus sp. Molecules 2022, 27, 7376. https://doi.org/10.3390/molecules27217376

AMA Style

Sun L, Wang H, Yan M, Sai C, Zhang Z. Research Advances of Bioactive Sesquiterpenoids Isolated from Marine-Derived Aspergillus sp. Molecules. 2022; 27(21):7376. https://doi.org/10.3390/molecules27217376

Chicago/Turabian Style

Sun, Lixiang, Huannan Wang, Maocai Yan, Chunmei Sai, and Zhen Zhang. 2022. "Research Advances of Bioactive Sesquiterpenoids Isolated from Marine-Derived Aspergillus sp." Molecules 27, no. 21: 7376. https://doi.org/10.3390/molecules27217376

APA Style

Sun, L., Wang, H., Yan, M., Sai, C., & Zhang, Z. (2022). Research Advances of Bioactive Sesquiterpenoids Isolated from Marine-Derived Aspergillus sp. Molecules, 27(21), 7376. https://doi.org/10.3390/molecules27217376

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