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Article

Tripeptide Leu-Ser-Trp Regulates the Vascular Endothelial Cells Phenotype Switching by Mediating the Vascular Smooth Muscle Cells-Derived Small Extracellular Vesicles Packaging of miR-145

by
Tianyuan Song
1,
Minzhi Zhou
1,
Wen Li
1,
Lin Zheng
1,2,
Jianping Wu
3 and
Mouming Zhao
1,2,*
1
School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China
2
Chaozhou Branch of Chemistry and Chemical Engineering Guangdong Laboratory, Chaozhou 521000, China
3
Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB T6G 2P5, Canada
*
Author to whom correspondence should be addressed.
Molecules 2022, 27(20), 7025; https://doi.org/10.3390/molecules27207025
Submission received: 20 September 2022 / Revised: 11 October 2022 / Accepted: 12 October 2022 / Published: 18 October 2022
(This article belongs to the Special Issue Bioactive Peptides: Emerging Fronts in Nutrition)
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Abstract

Tripeptide LSW, initially identified as a potent ACE inhibitory peptide from soybean protein, was recently reported to exert a protective effect against angiotensin II-induced endothelial dysfunction via extracellular vesicles (EVs). However, the molecular mechanisms, especially in lipid accumulation-induced atherosclerosis, still remain unclear. The study aimed to investigate whether the protective effects of LSW against endothelial dysfunction on vascular endothelial cells (VECs) was via vascular smooth muscle cells (VSMCs)-derived miRNA-145 packaged in EVs. The miRNA-145 was concentrated in EVs from LSW-treated VSMCs (LEVs), internalized into the HVUECs, and targeted the programmed cell death protein 4 (PDCD4) expression of HUVECs. Oxidized low-density lipoprotein (oxLDL) was applied to induce endothelial dysfunction in HUVECs; oxLDL-induced endothelial dysfunction in HUVECs was attenuated by PDCD4 knockout or LEVs incubation. The results of this study suggested a novel function of LSW as a regulator on the functional EVs from vascular cells in the oxLDL-induced atherosclerotic model.
Keywords: soybean protein-derived peptides; extracellular vesicles; miRNAs; HUVECs; atherosclerosis soybean protein-derived peptides; extracellular vesicles; miRNAs; HUVECs; atherosclerosis

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MDPI and ACS Style

Song, T.; Zhou, M.; Li, W.; Zheng, L.; Wu, J.; Zhao, M. Tripeptide Leu-Ser-Trp Regulates the Vascular Endothelial Cells Phenotype Switching by Mediating the Vascular Smooth Muscle Cells-Derived Small Extracellular Vesicles Packaging of miR-145. Molecules 2022, 27, 7025. https://doi.org/10.3390/molecules27207025

AMA Style

Song T, Zhou M, Li W, Zheng L, Wu J, Zhao M. Tripeptide Leu-Ser-Trp Regulates the Vascular Endothelial Cells Phenotype Switching by Mediating the Vascular Smooth Muscle Cells-Derived Small Extracellular Vesicles Packaging of miR-145. Molecules. 2022; 27(20):7025. https://doi.org/10.3390/molecules27207025

Chicago/Turabian Style

Song, Tianyuan, Minzhi Zhou, Wen Li, Lin Zheng, Jianping Wu, and Mouming Zhao. 2022. "Tripeptide Leu-Ser-Trp Regulates the Vascular Endothelial Cells Phenotype Switching by Mediating the Vascular Smooth Muscle Cells-Derived Small Extracellular Vesicles Packaging of miR-145" Molecules 27, no. 20: 7025. https://doi.org/10.3390/molecules27207025

APA Style

Song, T., Zhou, M., Li, W., Zheng, L., Wu, J., & Zhao, M. (2022). Tripeptide Leu-Ser-Trp Regulates the Vascular Endothelial Cells Phenotype Switching by Mediating the Vascular Smooth Muscle Cells-Derived Small Extracellular Vesicles Packaging of miR-145. Molecules, 27(20), 7025. https://doi.org/10.3390/molecules27207025

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