Why Matter Matters: Fast-Tracking Mycobacterium abscessus Drug Discovery

Round 1

Reviewer 1 Report

The authors wrote and captured all the biological results in a well-organized way, which can help readers to understand easily.

I suggest to the authors add figure on the first page, helping the readers to understand the background of this work.

In table 1 compound structure bonds vary from one to another one. Please make all structure should be in one format. 

Author Response

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Author Response File: Author Response.pdf

Reviewer 2 Report

The manuscript titled “Why Matter Matters: Fast-Tracking Mycobacterium abscessus Drug Discovery” reports an interesting work and authors focusing on the fast-tracking of novel preclinical candidates for Mycobacterium abscessus lung disease, they highlight the compounds for which in vivo proof-of-concept was demonstrated in an animal lung infection model. I include my comments below, most of them are suggestions to improve the overall quality of the publication. I considered the manuscript suitable for publication subject to the following improvements.

Overall, the study is well presented in a good way. However, some of the sentences include repetitive words and are not explained and cited appropriately.

Add a schematic diagram that may reveal both your proposed strategies and limitations of current treatments and drug discovery procedures.

The authors mentioned different drugs/molecules against M. abscessus, whereas, they didn’t mention the source or origin of the molecules.

Add future prospects and how computational methods can be used in such discoveries.

Author Response

Please see attachment

Author Response File: Author Response.pdf