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Article

Bioactive Properties of a Novel Antibacterial Dye Obtained from Laccase-Mediated Oxidation of 8-Anilino-1-naphthalenesulfonic Acid

by
Jolanta Polak
1,*,
Marcin Grąz
1,
Kamila Wlizło
2,
Katarzyna Szałapata
1,
Justyna Kapral-Piotrowska
3,
Roman Paduch
4 and
Anna Jarosz-Wilkołazka
1
1
Department of Biochemistry and Biotechnology, Institute of Biological Sciences, Maria Curie-Skłodowska University, 20-031 Lublin, Poland
2
Department of Industrial and Environmental Microbiology, Institute of Biological Sciences, Maria Curie-Skłodowska University, 20-031 Lublin, Poland
3
Department of Functional Anatomy and Cytobiology, Institute of Biological Sciences, Maria Curie-Skłodowska University, 20-031 Lublin, Poland
4
Department of Virology and Immunology, Institute of Biological Sciences, Maria Curie-Skłodowska University, 20-031 Lublin, Poland
*
Author to whom correspondence should be addressed.
Molecules 2022, 27(2), 487; https://doi.org/10.3390/molecules27020487
Submission received: 22 December 2021 / Revised: 7 January 2022 / Accepted: 10 January 2022 / Published: 13 January 2022
(This article belongs to the Special Issue Biocatalysis and Enzymes in Pharmaceutical and Biotechnological Processes)
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Abstract

Fungal laccase obtained from a Cerrena unicolor strain was used as an effective biocatalyst for the transformation of 8-anilino-1-naphthalenesulfonic acid into a green-coloured antibacterial compound, which can be considered as both an antimicrobial agent and a textile dye, simultaneously. The process of biosynthesis was performed in buffered solutions containing methanol as a co-solvent, allowing better solubilisation of substrate. The transformation process was optimised in terms of the buffer pH value, laccase activity, and concentrations of the substrate and co-solvent. The crude product obtained exhibited low cytotoxicity, antibacterial properties against Staphylococcus aureus and Staphylococcus epidermidis, and antioxidant properties. Moreover, the synthesised green-coloured compound proved non-allergenic and demonstrated a high efficiency of dyeing wool fibres.
Keywords: laccase; biocatalysis; bioactive compounds laccase; biocatalysis; bioactive compounds

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MDPI and ACS Style

Polak, J.; Grąz, M.; Wlizło, K.; Szałapata, K.; Kapral-Piotrowska, J.; Paduch, R.; Jarosz-Wilkołazka, A. Bioactive Properties of a Novel Antibacterial Dye Obtained from Laccase-Mediated Oxidation of 8-Anilino-1-naphthalenesulfonic Acid. Molecules 2022, 27, 487. https://doi.org/10.3390/molecules27020487

AMA Style

Polak J, Grąz M, Wlizło K, Szałapata K, Kapral-Piotrowska J, Paduch R, Jarosz-Wilkołazka A. Bioactive Properties of a Novel Antibacterial Dye Obtained from Laccase-Mediated Oxidation of 8-Anilino-1-naphthalenesulfonic Acid. Molecules. 2022; 27(2):487. https://doi.org/10.3390/molecules27020487

Chicago/Turabian Style

Polak, Jolanta, Marcin Grąz, Kamila Wlizło, Katarzyna Szałapata, Justyna Kapral-Piotrowska, Roman Paduch, and Anna Jarosz-Wilkołazka. 2022. "Bioactive Properties of a Novel Antibacterial Dye Obtained from Laccase-Mediated Oxidation of 8-Anilino-1-naphthalenesulfonic Acid" Molecules 27, no. 2: 487. https://doi.org/10.3390/molecules27020487

APA Style

Polak, J., Grąz, M., Wlizło, K., Szałapata, K., Kapral-Piotrowska, J., Paduch, R., & Jarosz-Wilkołazka, A. (2022). Bioactive Properties of a Novel Antibacterial Dye Obtained from Laccase-Mediated Oxidation of 8-Anilino-1-naphthalenesulfonic Acid. Molecules, 27(2), 487. https://doi.org/10.3390/molecules27020487

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