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Article

Therapeutic Effect of Icaritin on Cerebral Ischemia-Reperfusion-Induced Senescence and Apoptosis in an Acute Ischemic Stroke Mouse Model

by
Cheng-Tien Wu
1,2,†,
Ting-Hua Yang
3,†,
Man-Chih Chen
4,
Siao-Syun Guan
5,
Chang-Mu Chen
6,* and
Shing-Hwa Liu
4,7,8,*
1
Department of Nutrition, China Medical University, Taichung 406040, Taiwan
2
Master Program for Food and Drug Safety, China Medical University, Taichung 406040, Taiwan
3
Department of Otolaryngology, National Taiwan University Hospital, Taipei 10051, Taiwan
4
Institute of Toxicology, College of Medicine, National Taiwan University, Taipei 10051, Taiwan
5
Institute of Nuclear Energy Research, Atomic Energy Council, Taoyuan 32546, Taiwan
6
Division of Neurosurgery, Department of Surgery, College of Medicine and Hospital, National Taiwan University, Taipei 10051, Taiwan
7
Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 406040, Taiwan
8
Department of Pediatrics, College of Medicine and Hospital, National Taiwan University, Taipei 10051, Taiwan
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Molecules 2022, 27(18), 5783; https://doi.org/10.3390/molecules27185783
Submission received: 16 August 2022 / Revised: 3 September 2022 / Accepted: 5 September 2022 / Published: 7 September 2022
(This article belongs to the Section Medicinal Chemistry)
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Abstract

An ischemic stroke is brain damage caused by interruption of blood supply to the brain that can cause death and long-term disability. New medical strategies or therapies are urgently needed for ischemic stroke. Icaritin (ICT) is a metabolite of icariin (ICA), which are two active flavonoid components extracted from Herba epimedii and considered neuroprotective agents in animal models of Alzheimer’s disease and ischemic stroke. The therapeutic effect of ICT on ischemic still remains to be clarified. The aim of this study was to investigate the therapeutic effect of ICT on cerebral ischemia-reperfusion-associated senescence and apoptosis in a middle cerebral artery occlusion (MCAO) mouse model (ischemia for 50 min and reperfusion for 24 h). Administration of ICT after ischemia significantly reduced MCAO-induced neurological damage, infarct volume, and histopathological changes in the brain of acute ischemic stroke mice. ICT treatment could also reduce neuronal apoptosis and senescence and reversed the expression of apoptosis- and senescence-related signaling proteins. These findings suggest that ICT may have therapeutic potential to ameliorate acute ischemic stroke.
Keywords: ischemic stroke; icaritin; apoptosis; senescence ischemic stroke; icaritin; apoptosis; senescence

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MDPI and ACS Style

Wu, C.-T.; Yang, T.-H.; Chen, M.-C.; Guan, S.-S.; Chen, C.-M.; Liu, S.-H. Therapeutic Effect of Icaritin on Cerebral Ischemia-Reperfusion-Induced Senescence and Apoptosis in an Acute Ischemic Stroke Mouse Model. Molecules 2022, 27, 5783. https://doi.org/10.3390/molecules27185783

AMA Style

Wu C-T, Yang T-H, Chen M-C, Guan S-S, Chen C-M, Liu S-H. Therapeutic Effect of Icaritin on Cerebral Ischemia-Reperfusion-Induced Senescence and Apoptosis in an Acute Ischemic Stroke Mouse Model. Molecules. 2022; 27(18):5783. https://doi.org/10.3390/molecules27185783

Chicago/Turabian Style

Wu, Cheng-Tien, Ting-Hua Yang, Man-Chih Chen, Siao-Syun Guan, Chang-Mu Chen, and Shing-Hwa Liu. 2022. "Therapeutic Effect of Icaritin on Cerebral Ischemia-Reperfusion-Induced Senescence and Apoptosis in an Acute Ischemic Stroke Mouse Model" Molecules 27, no. 18: 5783. https://doi.org/10.3390/molecules27185783

APA Style

Wu, C.-T., Yang, T.-H., Chen, M.-C., Guan, S.-S., Chen, C.-M., & Liu, S.-H. (2022). Therapeutic Effect of Icaritin on Cerebral Ischemia-Reperfusion-Induced Senescence and Apoptosis in an Acute Ischemic Stroke Mouse Model. Molecules, 27(18), 5783. https://doi.org/10.3390/molecules27185783

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