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Article

Phytochemical Profile and Anticancer Potential of Endophytic Microorganisms from Liverwort Species, Marchantia polymorpha L.

1
Department of Pharmacognosy with the Medicinal Plant Garden, Medical University of Lublin, 20-093 Lublin, Poland
2
Department of Virology with SARS Laboratory, Medical University of Lublin, 20-093 Lublin, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Changsheng Zhang
Molecules 2022, 27(1), 153; https://doi.org/10.3390/molecules27010153
Received: 24 November 2021 / Revised: 16 December 2021 / Accepted: 26 December 2021 / Published: 28 December 2021
Liverwort endophytes could be a source of new biologically active substances, especially when these spore-forming plants are known to produce compounds that are not found in other living organisms. Despite the significant development of plant endophytes research, there are only a few studies describing liverwort endophytic microorganisms and their metabolites. In the presented study, the analysis of the volatile compounds obtained from thallose liverwort species, Marchantia polymorpha L., and its endophytes was carried out. For this purpose, non-polar extracts of plant material and symbiotic microorganisms were obtained. The extracts were analyzed using gas chromatography coupled to mass spectrometry. Compounds with the structure of diketopiperazine in the endophyte extract were identified. Liverwort volatile extract was a rich source of cuparane-, chamigrane-, acorane-, and thujopsane-type sesquiterpenoids. The cytotoxicity of ethyl acetate extracts from endophytic microorganisms was evaluated on a panel of cancer (FaDu, HeLa, and SCC-25) cell lines and normal (VERO), and revealed significant anticancer potential towards hypopharyngeal squamous cell carcinoma and cervical adenocarcinoma. View Full-Text
Keywords: liverworts; Marchantia polymorpha; endophytes; diketopiperazine; sesquiterpenoids; anticancer activity liverworts; Marchantia polymorpha; endophytes; diketopiperazine; sesquiterpenoids; anticancer activity
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MDPI and ACS Style

Stelmasiewicz, M.; Świątek, Ł.; Ludwiczuk, A. Phytochemical Profile and Anticancer Potential of Endophytic Microorganisms from Liverwort Species, Marchantia polymorpha L. Molecules 2022, 27, 153. https://doi.org/10.3390/molecules27010153

AMA Style

Stelmasiewicz M, Świątek Ł, Ludwiczuk A. Phytochemical Profile and Anticancer Potential of Endophytic Microorganisms from Liverwort Species, Marchantia polymorpha L. Molecules. 2022; 27(1):153. https://doi.org/10.3390/molecules27010153

Chicago/Turabian Style

Stelmasiewicz, Mateusz, Łukasz Świątek, and Agnieszka Ludwiczuk. 2022. "Phytochemical Profile and Anticancer Potential of Endophytic Microorganisms from Liverwort Species, Marchantia polymorpha L." Molecules 27, no. 1: 153. https://doi.org/10.3390/molecules27010153

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