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Open AccessReview

ROR: Nuclear Receptor for Melatonin or Not?

by 1,2, 1,2, 1,2, 2,3,* and 1,2,*
1
Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou 510055, China
2
Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510080, China
3
Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou 510080, China
*
Authors to whom correspondence should be addressed.
Academic Editors: Marcello Iriti and Dun-Xian Tan
Molecules 2021, 26(9), 2693; https://doi.org/10.3390/molecules26092693
Received: 1 April 2021 / Revised: 28 April 2021 / Accepted: 3 May 2021 / Published: 4 May 2021
Whether the retinoic acid-related orphan receptor (ROR) is a nuclear receptor of melatonin remains controversial. ROR is inextricably linked to melatonin in terms of its expression, function, and mechanism of action. Additionally, studies have illustrated that melatonin functions analogous to ROR ligands, thereby modulating the transcriptional activity of ROR. However, studies supporting these interactions have since been withdrawn. Furthermore, recent crystallographic evidence does not support the view that ROR is a nuclear receptor of melatonin. Some other studies have proposed that melatonin indirectly regulates ROR activity rather than directly binding to ROR. This review aims to delve into the complex relationship of the ROR receptor with melatonin in terms of its structure, expression, function, and mechanism. Thus, we provide the latest evidence and views on direct binding as well as indirect regulation of ROR by melatonin, dissecting both viewpoints in-depth to provide a more comprehensive perspective on this issue. View Full-Text
Keywords: retinoic acid-related orphan receptor; melatonin; nuclear receptor; ligand retinoic acid-related orphan receptor; melatonin; nuclear receptor; ligand
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MDPI and ACS Style

Ma, H.; Kang, J.; Fan, W.; He, H.; Huang, F. ROR: Nuclear Receptor for Melatonin or Not? Molecules 2021, 26, 2693. https://doi.org/10.3390/molecules26092693

AMA Style

Ma H, Kang J, Fan W, He H, Huang F. ROR: Nuclear Receptor for Melatonin or Not? Molecules. 2021; 26(9):2693. https://doi.org/10.3390/molecules26092693

Chicago/Turabian Style

Ma, Haozhen; Kang, Jun; Fan, Wenguo; He, Hongwen; Huang, Fang. 2021. "ROR: Nuclear Receptor for Melatonin or Not?" Molecules 26, no. 9: 2693. https://doi.org/10.3390/molecules26092693

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