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Microorganisms as a Potential Source of Molecules to Control Trypanosomatid Diseases

Departamento de Microbiología Ambiental y Biotecnología, Universidad Autónoma de Campeche, Av. Agustín Melgar s/n, Campeche 24039, Mexico
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Academic Editor: Gilles Comte
Molecules 2021, 26(5), 1388; https://doi.org/10.3390/molecules26051388
Received: 21 January 2021 / Revised: 25 February 2021 / Accepted: 1 March 2021 / Published: 4 March 2021
(This article belongs to the Section Natural Products Chemistry)
Trypanosomatids are the causative agents of leishmaniasis and trypanosomiasis, which affect about 20 million people in the world’s poorest countries, leading to 95,000 deaths per year. They are often associated with malnutrition, weak immune systems, low quality housing, and population migration. They are generally recognized as neglected tropical diseases. New drugs against these parasitic protozoa are urgently needed to counteract drug resistance, toxicity, and the high cost of commercially available drugs. Microbial bioprospecting for new molecules may play a crucial role in developing a new generation of antiparasitic drugs. This article reviews the current state of the available literature on chemically defined metabolites of microbial origin that have demonstrated antitrypanosomatid activity. In this review, bacterial and fungal metabolites are presented; they originate from a range of microorganisms, including cyanobacteria, heterotrophic bacteria, and filamentous fungi. We hope to provide a useful overview for future research to identify hits that may become the lead compounds needed to accelerate the discovery of new drugs against trypanosomatids. View Full-Text
Keywords: microbial metabolites; antitrypanosomatid agents; leishmaniasis; trypanosomiasis microbial metabolites; antitrypanosomatid agents; leishmaniasis; trypanosomiasis
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MDPI and ACS Style

Chan-Bacab, M.J.; Reyes-Estebanez, M.M.; Camacho-Chab, J.C.; Ortega-Morales, B.O. Microorganisms as a Potential Source of Molecules to Control Trypanosomatid Diseases. Molecules 2021, 26, 1388. https://doi.org/10.3390/molecules26051388

AMA Style

Chan-Bacab MJ, Reyes-Estebanez MM, Camacho-Chab JC, Ortega-Morales BO. Microorganisms as a Potential Source of Molecules to Control Trypanosomatid Diseases. Molecules. 2021; 26(5):1388. https://doi.org/10.3390/molecules26051388

Chicago/Turabian Style

Chan-Bacab, Manuel J.; Reyes-Estebanez, María M.; Camacho-Chab, Juan C.; Ortega-Morales, Benjamín O. 2021. "Microorganisms as a Potential Source of Molecules to Control Trypanosomatid Diseases" Molecules 26, no. 5: 1388. https://doi.org/10.3390/molecules26051388

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