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Article

Evaluation of Benzaldehyde as an Antibiotic Modulator and Its Toxic Effect against Drosophila melanogaster

1
Laboratory of Semi-Arid Bioprospecting (LABSEMA), Regional University of Cariri, Crato 63105-000, CE, Brazil
2
Graduate Program in Biological Chemistry, Regional University of Cariri, Crato 63105-000, CE, Brazil
3
Laboratory of Microbiology and Molecular Biology (LMBM), Regional University of Cariri (URCA), Crato 63105-000, CE, Brazil
4
Ferdows School of Paramedical and Health, Birjand University of Medical Sciences, Birjand 9717434765, Iran
5
Master of Internal Surgery Nursing, Birjand University of Medical Sciences, Birjand 9717434765, Iran
6
Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
*
Authors to whom correspondence should be addressed.
Academic Editors: Stefano Sabatini and Tommaso Felicetti
Molecules 2021, 26(18), 5570; https://doi.org/10.3390/molecules26185570
Received: 26 August 2021 / Revised: 7 September 2021 / Accepted: 9 September 2021 / Published: 13 September 2021
Products of natural origin remain important in the discovery of new bioactive molecules and are less damaging to the environment. Benzaldehyde is a product of the metabolism of plants, and similarly to oxygenated terpenes, it can have antibacterial activity against Staphylococcus aureus and toxic action against Drosophila melanogaster; we aimed to verify these activities. The broth microdilution tests determined the minimum inhibitory concentration (MIC) of benzaldehyde alone and in association with antibiotics and ethidium bromide (EtBr). Toxicity against Drosophila melanogaster was determined by fumigation tests that measured lethality and damage to the locomotor system. The results indicated that there was an association of norfloxacin and ciprofloxacin with benzaldehyde, from 64 μg/mL to 32 μg/mL of ciprofloxacin in the strain K6028 and from 256 μg/mL to 128 μg/mL of norfloxacin in the strain 1199B; however, the associations were not able to interfere with the functioning of the tested efflux pumps. In addition, benzaldehyde had a toxic effect on flies. Thus, the results proved the ability of benzaldehyde to modulate quinolone antibiotics and its toxic effects on fruit flies, thus enabling further studies in this area. View Full-Text
Keywords: antibacterial; toxicity; benzaldehyde; resistance; insecticide antibacterial; toxicity; benzaldehyde; resistance; insecticide
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MDPI and ACS Style

Neto, L.J.d.L.; Ramos, A.G.B.; Freitas, T.S.d.; Barbosa, C.R.d.S.; de Sousa Júnior, D.L.; Siyadatpanah, A.; Nejat, M.; Wilairatana, P.; Coutinho, H.D.M.; da Cunha, F.A.B. Evaluation of Benzaldehyde as an Antibiotic Modulator and Its Toxic Effect against Drosophila melanogaster. Molecules 2021, 26, 5570. https://doi.org/10.3390/molecules26185570

AMA Style

Neto LJdL, Ramos AGB, Freitas TSd, Barbosa CRdS, de Sousa Júnior DL, Siyadatpanah A, Nejat M, Wilairatana P, Coutinho HDM, da Cunha FAB. Evaluation of Benzaldehyde as an Antibiotic Modulator and Its Toxic Effect against Drosophila melanogaster. Molecules. 2021; 26(18):5570. https://doi.org/10.3390/molecules26185570

Chicago/Turabian Style

Neto, Luiz J.d.L., Andreza G.B. Ramos, Thiago S.d. Freitas, Cristina R.d.S. Barbosa, Dárcio L. de Sousa Júnior, Abolghasem Siyadatpanah, Morteza Nejat, Polrat Wilairatana, Henrique D.M. Coutinho, and Francisco A.B. da Cunha. 2021. "Evaluation of Benzaldehyde as an Antibiotic Modulator and Its Toxic Effect against Drosophila melanogaster" Molecules 26, no. 18: 5570. https://doi.org/10.3390/molecules26185570

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