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Review

Advantages of Hyaluronic Acid and Its Combination with Other Bioactive Ingredients in Cosmeceuticals

1
Department of Toxicology, Faculty of Pharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, 6 Pasteur Str., 400349 Cluj-Napoca, Romania
2
SC Aviva Cosmetics SRL, 71A Kövari Str., 400217 Cluj-Napoca, Romania
3
Preclinical Department, Faculty of Medicine, “Lucian Blaga” University of Sibiu, 2A Lucian Blaga Str., 550169 Sibiu, Romania
4
Department of Pharmacy, University of Napoli Federico II, Via D. Montesano 49, 80131 Napoli, Italy
*
Authors to whom correspondence should be addressed.
Academic Editors: María De La Luz Cádiz-Gurrea, Antonio Segura-Carretero and David Arráez-Román
Molecules 2021, 26(15), 4429; https://doi.org/10.3390/molecules26154429
Received: 7 June 2021 / Revised: 14 July 2021 / Accepted: 20 July 2021 / Published: 22 July 2021
(This article belongs to the Special Issue Bioactive Compounds for Cosmeceuticals against Skin Diseases)
This study proposes a review on hyaluronic acid (HA) known as hyaluronan or hyaluronate and its derivates and their application in cosmetic formulations. HA is a glycosaminoglycan constituted from two disaccharides (N-acetylglucosamine and D-glucuronic acid), isolated initially from the vitreous humour of the eye, and subsequently discovered in different tissues or fluids (especially in the articular cartilage and the synovial fluid). It is ubiquitous in vertebrates, including humans, and it is involved in diverse biological processes, such as cell differentiation, embryological development, inflammation, wound healing, etc. HA has many qualities that recommend it over other substances used in skin regeneration, with moisturizing and anti-ageing effects. HA molecular weight influences its penetration into the skin and its biological activity. Considering that, nowadays, hyaluronic acid has a wide use and a multitude of applications (in ophthalmology, arthrology, pneumology, rhinology, aesthetic medicine, oncology, nutrition, and cosmetics), the present study describes the main aspects related to its use in cosmetology. The biological effect of HA on the skin level and its potential adverse effects are discussed. Some available cosmetic products containing HA have been identified from the brand portfolio of most known manufacturers and their composition was evaluated. Further, additional biological effects due to the other active ingredients (plant extracts, vitamins, amino acids, peptides, proteins, saccharides, probiotics, etc.) are presented, as well as a description of their possible toxic effects. View Full-Text
Keywords: hyaluronic acid; cosmeceuticals; biological activity; skin health; moisturising effect; anti-ageing effect; bioactive compounds; molecular weight; hyaluronan derivates hyaluronic acid; cosmeceuticals; biological activity; skin health; moisturising effect; anti-ageing effect; bioactive compounds; molecular weight; hyaluronan derivates
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MDPI and ACS Style

Juncan, A.M.; Moisă, D.G.; Santini, A.; Morgovan, C.; Rus, L.-L.; Vonica-Țincu, A.L.; Loghin, F. Advantages of Hyaluronic Acid and Its Combination with Other Bioactive Ingredients in Cosmeceuticals. Molecules 2021, 26, 4429. https://doi.org/10.3390/molecules26154429

AMA Style

Juncan AM, Moisă DG, Santini A, Morgovan C, Rus L-L, Vonica-Țincu AL, Loghin F. Advantages of Hyaluronic Acid and Its Combination with Other Bioactive Ingredients in Cosmeceuticals. Molecules. 2021; 26(15):4429. https://doi.org/10.3390/molecules26154429

Chicago/Turabian Style

Juncan, Anca M., Dana G. Moisă, Antonello Santini, Claudiu Morgovan, Luca-Liviu Rus, Andreea L. Vonica-Țincu, and Felicia Loghin. 2021. "Advantages of Hyaluronic Acid and Its Combination with Other Bioactive Ingredients in Cosmeceuticals" Molecules 26, no. 15: 4429. https://doi.org/10.3390/molecules26154429

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