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Article

Antiviral, Antibacterial, Antifungal, and Cytotoxic Silver(I) BioMOF Assembled from 1,3,5-Triaza-7-Phoshaadamantane and Pyromellitic Acid

1
Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, 50-383 Wrocław, Poland
2
Department of Veterinary Microbiology, Wrocław University of Environmental and Life Sciences, Norwida 31, 50-375 Wrocław, Poland
3
Department of Animal Physiology and Biostructure, Wrocław University of Environmental and Life Sciences, Kożuchowska 1, 51-631 Wrocław, Poland
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Centro de Química Estrutural and Departamento de Engenharia Química, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049–001 Lisbon, Portugal
5
Research Institute of Chemistry, Peoples’ Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya st., 117198 Moscow, Russia
*
Authors to whom correspondence should be addressed.
Academic Editor: Kristof Van Hecke
Molecules 2020, 25(9), 2119; https://doi.org/10.3390/molecules25092119
Received: 15 April 2020 / Revised: 28 April 2020 / Accepted: 29 April 2020 / Published: 1 May 2020
(This article belongs to the Special Issue Metal Coordination Complexes for Biomedical Applications)
The present study reports the synthesis, characterization, and crystal structure of a novel bioactive metal-organic framework, [Ag4(µ-PTA)2(µ3-PTA)2(µ4-pma)(H2O)2]n·6nH2O (bioMOF 1), which was assembled from silver(I) oxide, 1,3,5-triaza-7-phosphaadamantane (PTA), and pyromellitic acid (H4pma). This product was isolated as a stable microcrystalline solid and characterized by standard methods, including elemental analysis, 1H and 31P{1H} NMR and FTIR spectroscopy, and single crystal X-ray diffraction. The crystal structure of 1 disclosed a very complex ribbon-pillared 3D metal-organic framework driven by three different types of bridging ligands (µ-PTA, µ3-PTA, and µ4-pma4−). Various bioactivity characteristics of bioMOF 1 were investigated, revealing that this compound acts as a potent antimicrobial against pathogenic strains of standard Gram-negative (Escherichia coli, Pseudomonas aeruginosa) and Gram-positive (Staphylococcus aureus) bacteria, as well as a yeast (Candida albicans). Further, 1 showed significant antiviral activity against human adenovirus 36 (HAdV-36). Finally, bioMOF 1 revealed high cytotoxicity toward an abnormal epithelioid cervix carcinoma (HeLa) cell line with low toxicity toward a normal human dermal fibroblast (NHDF) cell line. This study not only broadens the family of PTA-based coordination polymers but also highlights their promising multifaceted bioactivity. View Full-Text
Keywords: metal-organic frameworks; coordination polymers; silver complexes; 1,3,5-triaza-7-phosphaadamantane; pyromellitic acid; antimicrobial activity; cytotoxic activity; antiviral activity metal-organic frameworks; coordination polymers; silver complexes; 1,3,5-triaza-7-phosphaadamantane; pyromellitic acid; antimicrobial activity; cytotoxic activity; antiviral activity
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MDPI and ACS Style

Jaros, S.W.; Król, J.; Bażanów, B.; Poradowski, D.; Chrószcz, A.; Nesterov, D.S.; Kirillov, A.M.; Smoleński, P. Antiviral, Antibacterial, Antifungal, and Cytotoxic Silver(I) BioMOF Assembled from 1,3,5-Triaza-7-Phoshaadamantane and Pyromellitic Acid. Molecules 2020, 25, 2119. https://doi.org/10.3390/molecules25092119

AMA Style

Jaros SW, Król J, Bażanów B, Poradowski D, Chrószcz A, Nesterov DS, Kirillov AM, Smoleński P. Antiviral, Antibacterial, Antifungal, and Cytotoxic Silver(I) BioMOF Assembled from 1,3,5-Triaza-7-Phoshaadamantane and Pyromellitic Acid. Molecules. 2020; 25(9):2119. https://doi.org/10.3390/molecules25092119

Chicago/Turabian Style

Jaros, Sabina W.; Król, Jarosław; Bażanów, Barbara; Poradowski, Dominik; Chrószcz, Aleksander; Nesterov, Dmytro S.; Kirillov, Alexander M.; Smoleński, Piotr. 2020. "Antiviral, Antibacterial, Antifungal, and Cytotoxic Silver(I) BioMOF Assembled from 1,3,5-Triaza-7-Phoshaadamantane and Pyromellitic Acid" Molecules 25, no. 9: 2119. https://doi.org/10.3390/molecules25092119

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