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Antibacterial Natural Halimanes: Potential Source of Novel Antibiofilm Agents

Departamento de Química Orgánica, Facultad de Ciencias Químicas, University of Salamanca, Plaza de los Caídos 1-5, 37008 Salamanca, Spain
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These authors have contributed equally to this work.
Academic Editor: Artur M. S. Silva
Molecules 2020, 25(7), 1707; https://doi.org/10.3390/molecules25071707
Received: 25 February 2020 / Revised: 2 April 2020 / Accepted: 3 April 2020 / Published: 8 April 2020
(This article belongs to the Special Issue Application of Organic Synthesis to Bioactive Compounds II)
The development of new agents against bacteria is an urgent necessity for human beings. The structured colony of bacterial cells, called the biofilm, is used to defend themselves from biocide attacks. For this reason, it is necessary to know their structures, develop new agents to eliminate them and to develop new procedures that allow an early diagnosis, by using biomarkers. Among natural products, some derivatives of diterpenes with halimane skeleton show antibacterial activity. Some halimanes have been isolated from marine organisms, structurally related with halimanes isolated from Mycobacterium tuberculosis. These halimanes are being evaluated as virulence factors and as tuberculosis biomarkers, this disease being one of the major causes of mortality and morbidity. In this work, the antibacterial halimanes will be reviewed, with their structural characteristics, activities, sources and the synthesis known until now. View Full-Text
Keywords: halimanes; bacteria; marine origin; biofilm; diterpenes; tuberculosinol; isotuberculosinol; ent-halimic acid; synthesis halimanes; bacteria; marine origin; biofilm; diterpenes; tuberculosinol; isotuberculosinol; ent-halimic acid; synthesis
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MDPI and ACS Style

Tobal, I.E.; Roncero, A.M.; Moro, R.F.; Díez, D.; Marcos, I.S. Antibacterial Natural Halimanes: Potential Source of Novel Antibiofilm Agents. Molecules 2020, 25, 1707.

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