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Open AccessFeature PaperArticle

Antidepressant Potential of Lotus corniculatus L. subsp. corniculatus: An Ethnobotany Based Approach

1
Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, 06330 Etiler, Ankara, Turkey
2
Department of Pharmacy, Abdul Wali Khan University, Mardan 23200, Pakistan
3
Instituto de Investigación e Innovación en Salud, Facultad de Ciencias de la Salud, Universidad Central de Chile, 8330507 Santiago, Chile
4
Department of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain
*
Authors to whom correspondence should be addressed.
Academic Editor: Patrizia Russo
Molecules 2020, 25(6), 1299; https://doi.org/10.3390/molecules25061299
Received: 13 February 2020 / Revised: 27 February 2020 / Accepted: 10 March 2020 / Published: 12 March 2020
(This article belongs to the Special Issue Natural Products for Neurodegenerative Diseases)
As a Turkish traditional medicinal plant, aerial parts of Lotus corniculatus L. subsp. corniculatus (Fabaceae) are used as a painkiller, antihemoroidal, diuretic and sedative. In this study, the antidepressant potential of the plant has been attempted to clarify. Extracts with water, n-Hexane, ethyl acetate, and methanol were prepared respectively from the aerial parts. Antidepressant activity of the extracts were researched by using three different in vivo test models namely a tail suspension test, antagonism of tetrabenazine-induced hypothermia, ptosis, and suppression of locomotor activity and forced swimming test on male BALB/c mice and in vitro monoamine oxidase (MAO)-A and B inhibition assays. The results were evaluated through comparing with control and reference groups, and then active compounds of the active extract have been determined. Bioassay-guided fractionation of active fraction led to the isolation of three compounds and structures of the compounds were elucidated by spectroscopic methods. The data of this study demonstrate that the MeOH extract of the aerial parts of the plant showed remarkable in vivo antidepressant effect and the isolated compounds medicarpin-3-O-glucoside, gossypetin-3-O-glucoside and naringenin-7-O-glucoside (prunin) from the active sub-fractions could be responsible for the activity. Further mechanistic and toxicity studies are planned to develop new antidepressant-acting drugs. View Full-Text
Keywords: antidepressant; Lotus corniculatus; Fabaceae; forced swimming test; monoamine oxidase; tail suspension test; tetrabenazine antidepressant; Lotus corniculatus; Fabaceae; forced swimming test; monoamine oxidase; tail suspension test; tetrabenazine
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MDPI and ACS Style

Gürağaç Dereli, F.T.; Khan, H.; Sobarzo-Sánchez, E.; Akkol, E.K. Antidepressant Potential of Lotus corniculatus L. subsp. corniculatus: An Ethnobotany Based Approach. Molecules 2020, 25, 1299. https://doi.org/10.3390/molecules25061299

AMA Style

Gürağaç Dereli FT, Khan H, Sobarzo-Sánchez E, Akkol EK. Antidepressant Potential of Lotus corniculatus L. subsp. corniculatus: An Ethnobotany Based Approach. Molecules. 2020; 25(6):1299. https://doi.org/10.3390/molecules25061299

Chicago/Turabian Style

Gürağaç Dereli, Fatma T.; Khan, Haroon; Sobarzo-Sánchez, Eduardo; Akkol, Esra K. 2020. "Antidepressant Potential of Lotus corniculatus L. subsp. corniculatus: An Ethnobotany Based Approach" Molecules 25, no. 6: 1299. https://doi.org/10.3390/molecules25061299

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