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Article

Development of Provesicular Nanodelivery System of Curcumin as a Safe and Effective Antiviral Agent: Statistical Optimization, In Vitro Characterization, and Antiviral Effectiveness

by
Farid A. Badria
1,
Abdelaziz E. Abdelaziz
2,
Amira H. Hassan
3,
Abdullah A. Elgazar
4 and
Eman A. Mazyed
2,*
1
Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt
2
Department of Pharmaceutical Technology, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh 33516, Egypt
3
Department of Pharmaceutics, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62511, Egypt
4
Department of Pharmacognosy, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh 33516, Egypt
*
Author to whom correspondence should be addressed.
Molecules 2020, 25(23), 5668; https://doi.org/10.3390/molecules25235668
Submission received: 30 October 2020 / Revised: 24 November 2020 / Accepted: 28 November 2020 / Published: 1 December 2020
(This article belongs to the Special Issue Herbal Medicines as Antivirals)
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Abstract

Curcumin is a natural compound that has many medical applications. However, its low solubility and poor stability could impede its clinical applications. The present study aimed to formulate dry proniosomes to overcome these pitfalls and improve the therapeutic efficacy of Curcumin. Curcumin-loaded proniosomes were fabricated by the slurry method according to 32 factorial design using Design-Expert software to demonstrate the impact of different independent variables on entrapment efficiency (EE%) and % drug released after 12 h (Q12h). The optimized formula (F5) was selected according to the desirability criteria. F5 exhibited good flowability and appeared, after reconstitution, as spherical nanovesicles with EE% of 89.94 ± 2.31% and Q12h of 70.89 ± 1.62%. F5 demonstrated higher stability and a significant enhancement of Q12h than the corresponding niosomes. The docking study investigated the ability of Curcumin to bind effectively with the active site of DNA polymerase of Herpes simplex virus (HSV). The antiviral activity and the safety of F5 were significantly higher than Curcumin. F5 improved the safety of Acyclovir (ACV) and reduced its effective dose that produced a 100% reduction of viral plaques. Proniosomes could be promising stable carriers of Curcumin to be used as a safe and efficient antiviral agent.
Keywords: Curcumin; proniosomes; optimization; molecular docking; antiviral activity Curcumin; proniosomes; optimization; molecular docking; antiviral activity

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MDPI and ACS Style

Badria, F.A.; Abdelaziz, A.E.; Hassan, A.H.; Elgazar, A.A.; Mazyed, E.A. Development of Provesicular Nanodelivery System of Curcumin as a Safe and Effective Antiviral Agent: Statistical Optimization, In Vitro Characterization, and Antiviral Effectiveness. Molecules 2020, 25, 5668. https://doi.org/10.3390/molecules25235668

AMA Style

Badria FA, Abdelaziz AE, Hassan AH, Elgazar AA, Mazyed EA. Development of Provesicular Nanodelivery System of Curcumin as a Safe and Effective Antiviral Agent: Statistical Optimization, In Vitro Characterization, and Antiviral Effectiveness. Molecules. 2020; 25(23):5668. https://doi.org/10.3390/molecules25235668

Chicago/Turabian Style

Badria, Farid A., Abdelaziz E. Abdelaziz, Amira H. Hassan, Abdullah A. Elgazar, and Eman A. Mazyed. 2020. "Development of Provesicular Nanodelivery System of Curcumin as a Safe and Effective Antiviral Agent: Statistical Optimization, In Vitro Characterization, and Antiviral Effectiveness" Molecules 25, no. 23: 5668. https://doi.org/10.3390/molecules25235668

APA Style

Badria, F. A., Abdelaziz, A. E., Hassan, A. H., Elgazar, A. A., & Mazyed, E. A. (2020). Development of Provesicular Nanodelivery System of Curcumin as a Safe and Effective Antiviral Agent: Statistical Optimization, In Vitro Characterization, and Antiviral Effectiveness. Molecules, 25(23), 5668. https://doi.org/10.3390/molecules25235668

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