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Open AccessArticle

Correlations Between Trace Elements in Selected Locations of the Human Brain in Individuals with Alcohol Use Disorder

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Department of Anatomy, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland
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Department of Neurosurgery and Pediatric Neurosurgery, Medical University of Lublin, Jaczewskiego 8, 20-954 Lublin, Poland
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Faculty of Chemistry, Department of Analytical Chemistry, Adam Mickiewicz University in Poznań, 89B Umultowska Street, 61-614 Poznan, Poland
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Department of Applied Mathematics, University of Technology, Nadbystrzycka 38D, 20-618 Lublin, Poland
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Department of Analytical Chemistry, Medical University of Lublin, Chodźki 4a, 20-093 Lublin, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Ki-Jung Paeng
Molecules 2020, 25(2), 359; https://doi.org/10.3390/molecules25020359
Received: 11 November 2019 / Revised: 5 January 2020 / Accepted: 10 January 2020 / Published: 15 January 2020
(This article belongs to the Special Issue Forensic Analytical Chemistry)
Trace element distribution varies in different locations of the human brain. Several elements were found to cause various negative effects, such as neurodegeneration. In this paper, we analyzed the interactions between seven trace elements: zinc (Zn), selenium (Se), manganese (Mg), iron (Fe), copper (Cu), chromium (Cr) and cobalt (Co) in individuals with alcohol use disorder (AUD) and individuals without (control group). Brain tissue samples from 31 individuals with AUD and 31 control subjects were harvested. Inductively coupled plasma optical emission spectrometry was used for trace element determination. In the control group, there were several positive correlations between Cr, Cu, Fe and Mn. In the AUD group, positive correlations between Co and Cr, Cu, Fe, Mn, Zn were found. The majority of correlations between Zn and other elements are positive. In the studied group, Mn had strong positive correlations with Co, Cr, Cu and Fe. The strongest positive correlation found between average element concentration was between Cu and Cr. The knowledge of kinetics and metabolism of trace elements as well as the impact of alcohol on these processes is essential for understanding the pathological processes and functioning of human brain tissue. View Full-Text
Keywords: trace elements; correlation; brain; alcohol; alcohol use disorder trace elements; correlation; brain; alcohol; alcohol use disorder
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Grochowski, C.; Szukała, M.; Litak, J.; Budny, A.; Proch, J.; Majerek, D.; Blicharska, E.; Niedzielski, P. Correlations Between Trace Elements in Selected Locations of the Human Brain in Individuals with Alcohol Use Disorder. Molecules 2020, 25, 359.

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