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Open AccessArticle

Bioadhesive Polymeric Films Based on Red Onion Skins Extract for Wound Treatment: An Innovative and Eco-Friendly Formulation

1
Department of Pharmaceutical Sciences, University of Perugia, via del Liceo 1, 06123 Perugia, Italy
2
Department of Molecular Biotechnology and Health Sciences, Sect. Analytical Chemistry, Via Pietro Giuria 5, 10125 Torino, Italy
3
Department of Experimental Medicine, Sect. Pharmacology, University of Perugia, P.le L. Severi 1, Bld C/4th floor, 06132 Perugia, Italy
4
Istituto Zooprofilattico dell’Umbria e delle Marche, via G. Salvemini, 1, 06126 Perugia, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Raffaele Capasso and Lorenzo Di Cesare Mannelli
Molecules 2020, 25(2), 318; https://doi.org/10.3390/molecules25020318
Received: 29 November 2019 / Revised: 9 January 2020 / Accepted: 10 January 2020 / Published: 13 January 2020
(This article belongs to the Special Issue Plant Extracts: Biological and Pharmacological Activity)
The onion non-edible outside layers represent a widely available waste material deriving from its processing and consumption. As onion is a vegetable showing many beneficial properties for human health, a study aiming to evaluate the use of extract deriving from the non-edible outside layers was planned. An eco-friendly extraction method was optimized using a hydroalcoholic solution as solvent. The obtained extract was deeply characterized by in vitro methods and then formulated in autoadhesive, biocompatible and pain-free hydrogel polymeric films. The extract, very soluble in water, showed antioxidant, radical scavenging, antibacterial and anti-inflammatory activities, suggesting a potential dermal application for wounds treatment. In vitro studies showed a sustained release of the extract from the hydrogel polymeric film suitable to reach concentrations necessary for both antibacterial and anti-inflammatory activities. Test performed on human keratinocytes showed that the formulation is safe suggesting that the projected formulation could be a valuable tool for wound treatment. View Full-Text
Keywords: onion skins extract; hydrogel; polymeric films; anti-inflammatory; antibacterial onion skins extract; hydrogel; polymeric films; anti-inflammatory; antibacterial
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Pagano, C.; Marinozzi, M.; Baiocchi, C.; Beccari, T.; Calarco, P.; Ceccarini, M.R.; Chielli, M.; Orabona, C.; Orecchini, E.; Ortenzi, R.; Ricci, M.; Scuota, S.; Tiralti, M.C.; Perioli, L. Bioadhesive Polymeric Films Based on Red Onion Skins Extract for Wound Treatment: An Innovative and Eco-Friendly Formulation. Molecules 2020, 25, 318.

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