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Article

Chemical Composition, Antimicrobial, Antioxidant, and Antiproliferative Properties of Grapefruit Essential Oil Prepared by Molecular Distillation

National Navel Orange Engineering Research Center, College of Life Sciences, Gannan Normal University, Ganzhou 341000, China
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Author to whom correspondence should be addressed.
Academic Editor: Raffaele Capasso
Molecules 2020, 25(1), 217; https://doi.org/10.3390/molecules25010217
Received: 3 December 2019 / Revised: 24 December 2019 / Accepted: 3 January 2020 / Published: 5 January 2020
(This article belongs to the Special Issue Plant Extracts: Biological and Pharmacological Activity)
Grapefruit essential oil has been proven to have wide range of bioactivities. However, bioactivity of its molecular distillate has not been well studied. In this study, a light phase oil was obtained by molecular distillation from cold-pressed grapefruit essential oil and GC-MS was used to identify its chemical composition. The antimicrobial activity of the light phase oil was tested by filter paper diffusion method, and the anticancer activity was determined by the Cell Counting Kit-8 (CCK-8) assay. Twenty-four components were detected with a total relative content of 99.74%, including 97.48% of terpenes and 1.66% of oxygenated terpenes. The light phase oil had the best antimicrobial effect on Bacillus subtilis, followed by Escherichia coli, Staphylococcus aureus and Salmonellaty phimurium. DPPH and ABTS assays demonstrated that the light phase oil had good antioxidant activity. The CCK-8 assay of cell proliferation showed that the light phase oil had a good inhibitory effect on the proliferation of HepG2 liver cancer cells and HCT116 colon cancer cells. View Full-Text
Keywords: grapefruit essential oil; molecular distillation; GC-MS; antimicrobial; antioxidant; anticancer activity grapefruit essential oil; molecular distillation; GC-MS; antimicrobial; antioxidant; anticancer activity
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MDPI and ACS Style

Deng, W.; Liu, K.; Cao, S.; Sun, J.; Zhong, B.; Chun, J. Chemical Composition, Antimicrobial, Antioxidant, and Antiproliferative Properties of Grapefruit Essential Oil Prepared by Molecular Distillation. Molecules 2020, 25, 217. https://doi.org/10.3390/molecules25010217

AMA Style

Deng W, Liu K, Cao S, Sun J, Zhong B, Chun J. Chemical Composition, Antimicrobial, Antioxidant, and Antiproliferative Properties of Grapefruit Essential Oil Prepared by Molecular Distillation. Molecules. 2020; 25(1):217. https://doi.org/10.3390/molecules25010217

Chicago/Turabian Style

Deng, Weihui, Ke Liu, Shan Cao, Jingyu Sun, Balian Zhong, and Jiong Chun. 2020. "Chemical Composition, Antimicrobial, Antioxidant, and Antiproliferative Properties of Grapefruit Essential Oil Prepared by Molecular Distillation" Molecules 25, no. 1: 217. https://doi.org/10.3390/molecules25010217

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