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Mass Spectrometry and Structural Biology Techniques in the Studies on the Coronavirus-Receptor Interaction

Institute of Health Sciences, Opole University, Katowicka 68, 45-060 Opole, Poland
Academic Editor: Derek J. McPhee
Molecules 2020, 25(18), 4133; https://doi.org/10.3390/molecules25184133
Received: 1 August 2020 / Revised: 1 September 2020 / Accepted: 9 September 2020 / Published: 10 September 2020
(This article belongs to the Special Issue Mass Spectrometric Proteomics II)
Mass spectrometry and some other biophysical methods, have made substantial contributions to the studies on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and human proteins interactions. The most interesting feature of SARS-CoV-2 seems to be the structure of its spike (S) protein and its interaction with the human cell receptor. Mass spectrometry of spike S protein revealed how the glycoforms are distributed across the S protein surface. X-ray crystallography and cryo-electron microscopy made huge impact on the studies on the S protein and ACE2 receptor protein interaction, by elucidating the three-dimensional structures of these proteins and their conformational changes. The findings of the most recent studies in the scope of SARS-CoV-2-Human protein-protein interactions are described here. View Full-Text
Keywords: spike protein-ACE2 interaction; MS; structural techniques; glycosylation; SARS coronavirus spike protein-ACE2 interaction; MS; structural techniques; glycosylation; SARS coronavirus
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Witkowska, D. Mass Spectrometry and Structural Biology Techniques in the Studies on the Coronavirus-Receptor Interaction. Molecules 2020, 25, 4133.

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