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Open AccessFeature PaperReview

Prevailing Knowledge on the Bioavailability and Biological Activities of Sulphur Compounds from Alliums: A Potential Drug Candidate

1
Department of Medical Microbiology and Parasitology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Malaysia
2
Department of Mechanical Engineering, Indian Institute of Technology, Kharagpur 721302, India
3
Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Malaysia
*
Author to whom correspondence should be addressed.
Academic Editors: Masayoshi Shigyo and Mostafa Abdelrahman
Molecules 2020, 25(18), 4111; https://doi.org/10.3390/molecules25184111
Received: 9 July 2020 / Revised: 15 August 2020 / Accepted: 23 August 2020 / Published: 9 September 2020
(This article belongs to the Special Issue Alliums: Traditional Uses, Phytochemistry and Biological Activities)
Allium sativum (garlic) is widely known and is consumed as a natural prophylactic worldwide. It produces more than 200 identified chemical compounds, with more than 20 different kinds of sulfide compounds. The sulfide compounds particularly are proven to contribute to its various biological roles and pharmacological properties such as antimicrobial, antithrombotic, hypoglycemic, antitumour, and hypolipidemic. Therefore, it is often referred as disease-preventive food. Sulphur-containing compounds from A. sativum are derivatives of S-alkenyl-l-cysteine sulfoxides, ajoene molecules, thiosulfinates, sulfides, and S-allylcysteine. This review presents an overview of the water-soluble and oil-soluble sulphur based phytochemical compounds present in garlic, highlighting their mechanism of action in treating various health conditions. However, its role as a therapeutic agent should be extensively studied as it depends on factors such as the effective dosage and the suitable method of preparation. View Full-Text
Keywords: garlic; Allium sativum; sulphur compounds; cardiovascular diseases; obesity; cancer garlic; Allium sativum; sulphur compounds; cardiovascular diseases; obesity; cancer
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MDPI and ACS Style

Subramanian, M.S.; Nandagopal MS, G.; Amin Nordin, S.; Thilakavathy, K.; Joseph, N. Prevailing Knowledge on the Bioavailability and Biological Activities of Sulphur Compounds from Alliums: A Potential Drug Candidate. Molecules 2020, 25, 4111.

AMA Style

Subramanian MS, Nandagopal MS G, Amin Nordin S, Thilakavathy K, Joseph N. Prevailing Knowledge on the Bioavailability and Biological Activities of Sulphur Compounds from Alliums: A Potential Drug Candidate. Molecules. 2020; 25(18):4111.

Chicago/Turabian Style

Subramanian, Murugan S.; Nandagopal MS, Giri; Amin Nordin, Syafinaz; Thilakavathy, Karuppiah; Joseph, Narcisse. 2020. "Prevailing Knowledge on the Bioavailability and Biological Activities of Sulphur Compounds from Alliums: A Potential Drug Candidate" Molecules 25, no. 18: 4111.

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