Next Article in Journal
Observation of Enhanced Dissociative Photochemistry in the Non-Native Nucleobase 2-Thiouracil
Next Article in Special Issue
Modeling of the Production of Lipid Microparticles Using PGSS® Technique
Previous Article in Journal
Stabilisation of Exotic Tribromide (Br3) Anions via Supramolecular Interaction with a Tosylated Macrocyclic Pyridinophane. A Serendipitous Case
Previous Article in Special Issue
Biobased Cryogels from Enzymatically Oxidized Starch: Functionalized Materials as Carriers of Active Molecules
Review

Technologies and Formulation Design of Polysaccharide-Based Hydrogels for Drug Delivery

1
Department of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, I—84084 Fisciano (SA), Italy
2
Department of Pharmacy and Pharmaceutical Technology, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Derek McPhee
Molecules 2020, 25(14), 3156; https://doi.org/10.3390/molecules25143156
Received: 5 June 2020 / Revised: 29 June 2020 / Accepted: 2 July 2020 / Published: 10 July 2020
(This article belongs to the Special Issue Biopolymers in Drug Delivery and Regenerative Medicine)
Polysaccharide-based hydrogel particles (PbHPs) are very promising carriers aiming to control and target the release of drugs with different physico-chemical properties. Such delivery systems can offer benefits through the proper encapsulation of many drugs (non-steroidal and steroidal anti-inflammatory drugs, antibiotics, etc) ensuring their proper release and targeting. This review discusses the different phases involved in the production of PbHPs in pharmaceutical technology, such as droplet formation (SOL phase), sol-gel transition of the droplets (GEL phase) and drying, as well as the different methods available for droplet production with a special focus on prilling technique. In addition, an overview of the various droplet gelation methods with particular emphasis on ionic cross-linking of several polysaccharides enabling the formation of particles with inner highly porous network or nanofibrillar structure is given. Moreover, a detailed survey of the different inner texture, in xerogels, cryogels or aerogels, each with specific arrangement and properties, which can be obtained with different drying methods, is presented. Various case studies are reported to highlight the most appropriate application of such systems in pharmaceutical field. We also describe the challenges to be faced for the breakthrough towards clinic studies and, finally, the market, focusing on the useful approach of safety-by-design (SbD). View Full-Text
Keywords: polysaccharides; hydrogels; prilling; droplets; ionotropic gelation; drying; xerogels; cryogels; aerogels polysaccharides; hydrogels; prilling; droplets; ionotropic gelation; drying; xerogels; cryogels; aerogels
Show Figures

Figure 1

MDPI and ACS Style

Auriemma, G.; Russo, P.; Del Gaudio, P.; García-González, C.A.; Landín, M.; Aquino, R.P. Technologies and Formulation Design of Polysaccharide-Based Hydrogels for Drug Delivery. Molecules 2020, 25, 3156. https://doi.org/10.3390/molecules25143156

AMA Style

Auriemma G, Russo P, Del Gaudio P, García-González CA, Landín M, Aquino RP. Technologies and Formulation Design of Polysaccharide-Based Hydrogels for Drug Delivery. Molecules. 2020; 25(14):3156. https://doi.org/10.3390/molecules25143156

Chicago/Turabian Style

Auriemma, Giulia, Paola Russo, Pasquale Del Gaudio, Carlos A. García-González, Mariana Landín, and Rita P. Aquino 2020. "Technologies and Formulation Design of Polysaccharide-Based Hydrogels for Drug Delivery" Molecules 25, no. 14: 3156. https://doi.org/10.3390/molecules25143156

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop