Examining the Effects of (α4)3(β2)2 Nicotinic Acetylcholine Receptor-Selective Positive Allosteric Modulator on Acute Thermal Nociception in Rats
Abstract
:1. Introduction
2. Results
2.1. Effect of dFBr and CMPI on Acute Thermal Nociception Behavior in Hot Plate Test
2.2. Effect of dFBr and CMPI on Acute Thermal Nociception Behavior in Tail Flick Test
2.3. Effect of dFBr on Nicotine-Induced Acute Thermal Antinociception
2.4. Rat Sex Does Not Influence dFBr and CMPI Modulation of Acute Thermal Nociception
3. Discussion
4. Materials and Methods
4.1. Animals
4.2. Drugs
4.3. Acute Thermal Nociceptive Tests
4.3.1. Hot Plate Test
4.3.2. Tail Flick Test
4.4. Data Analyses
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Deba, F.; Ramos, K.; Vannoy, M.; Munoz, K.; Akinola, L.S.; Damaj, M.I.; Hamouda, A.K. Examining the Effects of (α4)3(β2)2 Nicotinic Acetylcholine Receptor-Selective Positive Allosteric Modulator on Acute Thermal Nociception in Rats. Molecules 2020, 25, 2923. https://doi.org/10.3390/molecules25122923
Deba F, Ramos K, Vannoy M, Munoz K, Akinola LS, Damaj MI, Hamouda AK. Examining the Effects of (α4)3(β2)2 Nicotinic Acetylcholine Receptor-Selective Positive Allosteric Modulator on Acute Thermal Nociception in Rats. Molecules. 2020; 25(12):2923. https://doi.org/10.3390/molecules25122923
Chicago/Turabian StyleDeba, Farah, Kara Ramos, Matthew Vannoy, Kemburli Munoz, Lois S. Akinola, M. Imad Damaj, and Ayman K. Hamouda. 2020. "Examining the Effects of (α4)3(β2)2 Nicotinic Acetylcholine Receptor-Selective Positive Allosteric Modulator on Acute Thermal Nociception in Rats" Molecules 25, no. 12: 2923. https://doi.org/10.3390/molecules25122923