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(‒)-Cannabidiolic Acid, a Still Overlooked Bioactive Compound: An Introductory Review and Preliminary Research

1
Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania “Luigi Vanvitelli”, Via Vivaldi 43, 81100 Caserta, Italy
2
Department of Engineering, University of Campania “Luigi Vanvitelli”, Via Roma 29, I-81031 Aversa, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Laura De Martino
Molecules 2020, 25(11), 2638; https://doi.org/10.3390/molecules25112638
Received: 1 May 2020 / Revised: 26 May 2020 / Accepted: 4 June 2020 / Published: 5 June 2020
(This article belongs to the Special Issue Industrial Hemp Chemistry and Nutraceutical Perspectives)
Cannabidiolic acid (CBDA) is the main phytocannabinoid in fiber and seed-oil hemp (Cannabis sativa L.) plants, but its potential health-related capabilities have been masked for years by a greater scientific interest towards its neutral derivative cannabidiol (CBD). This review aims to collect from the literature and critically discuss all the information about this molecule, starting from its biosynthesis, and focusing on its bioactivity, as an anti-inflammatory, anti-emetic, anti-convulsant, and anti-cancerogenic drug. Furthermore, in the awareness that, despite its multiple bioactive effects, currently poor efforts have been made to achieve its reliable purification, herein, we propose a relatively simple, fast, and inexpensive procedure for its recovery from pollen of industrial hemp cultivars. Spectroscopic and spectrometric techniques allowed us to unequivocally identify pure isolated CBDA and to distinguish it from the constitutional isomer tetrahydrocannabinolic acid (THCA-A). View Full-Text
Keywords: cannabidiolic acid; Cannabis sativa L.; hemp pollen; spectroscopic techniques; mass spectrometric techniques cannabidiolic acid; Cannabis sativa L.; hemp pollen; spectroscopic techniques; mass spectrometric techniques
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MDPI and ACS Style

Formato, M.; Crescente, G.; Scognamiglio, M.; Fiorentino, A.; Pecoraro, M.T.; Piccolella, S.; Catauro, M.; Pacifico, S. (‒)-Cannabidiolic Acid, a Still Overlooked Bioactive Compound: An Introductory Review and Preliminary Research. Molecules 2020, 25, 2638. https://doi.org/10.3390/molecules25112638

AMA Style

Formato M, Crescente G, Scognamiglio M, Fiorentino A, Pecoraro MT, Piccolella S, Catauro M, Pacifico S. (‒)-Cannabidiolic Acid, a Still Overlooked Bioactive Compound: An Introductory Review and Preliminary Research. Molecules. 2020; 25(11):2638. https://doi.org/10.3390/molecules25112638

Chicago/Turabian Style

Formato, Marialuisa, Giuseppina Crescente, Monica Scognamiglio, Antonio Fiorentino, Maria T. Pecoraro, Simona Piccolella, Michelina Catauro, and Severina Pacifico. 2020. "(‒)-Cannabidiolic Acid, a Still Overlooked Bioactive Compound: An Introductory Review and Preliminary Research" Molecules 25, no. 11: 2638. https://doi.org/10.3390/molecules25112638

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