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Open AccessArticle

Evaluation of the Anticancer Activities of Novel Transition Metal Complexes with Berenil and Nitroimidazole

1
Department of Synthesis and Technology of Drugs, Medical University of Bialystok, Kilinskiego 1, 15-089 Bialystok, Poland
2
Department of Pharmacodynamics, Medical University of Bialystok, Mickiewicza 2c, 15-222 Bialystok, Poland
3
Department of Medicinal Chemistry, Medical University of Bialystok, Mickiewicza 2c, 15-222 Bialystok, Poland
4
Department of Biotechnology, Medical University of Bialystok, Kilinskiego 1, 15-089 Bialystok, Poland
*
Author to whom correspondence should be addressed.
Academic Editors: Chiara Brullo and Bruno Tasso
Molecules 2020, 25(12), 2860; https://doi.org/10.3390/molecules25122860
Received: 29 May 2020 / Revised: 17 June 2020 / Accepted: 20 June 2020 / Published: 21 June 2020
(This article belongs to the Special Issue Anticancer Compounds with Different Biological Targets)
Novel transition metal complexes (Au, Pd, Pt) with berenil and 2-(1-methyl-5-nitroimidazol-2-yl)ethanol were obtained through two-step synthesis. The cytotoxicity assay against MCF-7 and MDA-MB-231 breast cancer cells revealed that novel platinum and palladium complexes cause a reduction on the viability of MCF-7 and MDA-MB-231 breast cancer cells to a greater extent than cisplatin. The complexes showed lower cytotoxicity on normal MCF-10A human breast epithelial cells than on tumor cells. Furthermore, we observed that these complexes selectively concentrate in tumor cell mitochondria due to the characteristic for these cells increased membrane potential that may explain their increased proapoptotic activity. The activity of the synthesized compounds against topoisomerase type IIα and their increased impact on DNA defragmentation also were documented. The novel complexes also induced autophagosome changes and inhibited tumor growth in xenograft models (established using breast cancer cells). View Full-Text
Keywords: anticancer compounds; multi-factorial compounds; transition metal complexes; nitroimidazole; breast cancer anticancer compounds; multi-factorial compounds; transition metal complexes; nitroimidazole; breast cancer
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Czarnomysy, R.; Radomska, D.; Muszyńska, A.; Hermanowicz, J.M.; Prokop, I.; Bielawska, A.; Bielawski, K. Evaluation of the Anticancer Activities of Novel Transition Metal Complexes with Berenil and Nitroimidazole. Molecules 2020, 25, 2860.

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