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Article

Effect of Palmitic Acid on Exosome-Mediated Secretion and Invasive Motility in Prostate Cancer Cells

Department of Physiology and Biophysics, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY 14203, USA
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Author to whom correspondence should be addressed.
Academic Editor: Pierluigi Plastina
Molecules 2020, 25(12), 2722; https://doi.org/10.3390/molecules25122722
Received: 15 May 2020 / Revised: 7 June 2020 / Accepted: 11 June 2020 / Published: 12 June 2020
(This article belongs to the Special Issue Lipids in Health and Disease)
High fat consumption can enhance metastasis and decrease survival in prostate cancer, but the picture remains incomplete on the epidemiological and cell-biological level, impeding progress toward individualized recommendations in the clinic. Recent work has highlighted the role of exosomes secreted by prostate cancer cells in the progression of the disease, particularly in metastatic invasion, and also the utility of targeting these extracellular vesicles for diagnostics, as carriers of disease progression markers. Here, we investigated the question of a potential impact of the chief nutritional saturated fatty acid on the exosome secretion. Palmitic acid decreased the secretion of exosomes in human prostate cancer cells in vitro in a concentration-dependent manner. At the same time, the content of some prospective metastatic markers in the secreted exosomal fraction was also reduced, as was the ability of the cells to invade across extracellular matrix barriers. While by themselves our in vitro results imply that on the cell level, palmitic acid may be beneficial vis-à-vis the course of the disease, they also suggest that, by virtue of the decreased biomarker secretion, palmitic acid has the potential to cause unjustified deprioritization of treatment in obese and lipidemic men. View Full-Text
Keywords: palmitic acid; fatty acids; prostate cancer; migration; invasion; exosomes; caveolin-1; secretion palmitic acid; fatty acids; prostate cancer; migration; invasion; exosomes; caveolin-1; secretion
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MDPI and ACS Style

Maly, I.V.; Hofmann, W.A. Effect of Palmitic Acid on Exosome-Mediated Secretion and Invasive Motility in Prostate Cancer Cells. Molecules 2020, 25, 2722. https://doi.org/10.3390/molecules25122722

AMA Style

Maly IV, Hofmann WA. Effect of Palmitic Acid on Exosome-Mediated Secretion and Invasive Motility in Prostate Cancer Cells. Molecules. 2020; 25(12):2722. https://doi.org/10.3390/molecules25122722

Chicago/Turabian Style

Maly, Ivan V., and Wilma A. Hofmann 2020. "Effect of Palmitic Acid on Exosome-Mediated Secretion and Invasive Motility in Prostate Cancer Cells" Molecules 25, no. 12: 2722. https://doi.org/10.3390/molecules25122722

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