Next Article in Journal
NMR-Based Chemical Profiling, Isolation and Evaluation of the Cytotoxic Potential of the Diterpenoid Siderol from Cultivated Sideritis euboea Heldr.
Next Article in Special Issue
A Direct Silanization Protocol for Dialdehyde Cellulose
Previous Article in Journal
Ras and Wnt Interaction Contribute in Prostate Cancer Bone Metastasis
Previous Article in Special Issue
Feasibility of Barley Straw Fibers as Reinforcement in Fully Biobased Polyethylene Composites: Macro and Micro Mechanics of the Flexural Strength
Open AccessArticle

Production and Mechanical Characterisation of TEMPO-Oxidised Cellulose Nanofibrils/β-Cyclodextrin Films and Cryogels

1
Univeristy Grenoble Alpes, CNRS, Grenoble INP*, LGP2, 38000 Grenoble, France
2
RISE PFI, NO-7491 Trondheim, Norway
3
Departments of Chemical Engineering, NTNU, 7491 Trondheim, Norway
*
Author to whom correspondence should be addressed.
Molecules 2020, 25(10), 2381; https://doi.org/10.3390/molecules25102381
Received: 20 April 2020 / Revised: 15 May 2020 / Accepted: 18 May 2020 / Published: 20 May 2020
(This article belongs to the Special Issue Lignocellulosic Biomass)
Wood-based TEMPO-oxidised cellulose nanofibrils (toCNF) are promising materials for biomedical applications. Cyclodextrins have ability to form inclusion complexes with hydrophobic molecules and are considered as a method to bring new functionalities to these materials. Water sorption and mechanical properties are also key properties for biomedical applications such as drug delivery and tissue engineering. In this work, we report the modification with β-cyclodextrin (βCD) of toCNF samples with different carboxyl contents viz. 756 ± 4 µmol/g and 1048 ± 32 µmol/g. The modification was carried out at neutral and acidic pH (2.5) to study the effect of dissociation of the carboxylic acid group. Films processed by casting/evaporation at 40 °C and cryogels processed by freeze-drying were prepared from βCD modified toCNF suspensions and compared with reference samples of unmodified toCNF. The impact of modification on water sorption and mechanical properties was assessed. It was shown that the water sorption behaviour for films is driven by adsorption, with a clear impact of the chemical makeup of the fibres (charge content, pH, and adsorption of cyclodextrin). Modified toCNF cryogels (acidic pH and addition of cyclodextrins) displayed lower mechanical properties linked to the modification of the cell wall porosity structure. Esterification between βCD and toCNF under acidic conditions was performed by freeze-drying, and such cryogels exhibited a lower decrease in mechanical properties in the swollen state. These results are promising for the development of scaffold and films with controlled mechanical properties and added value due to the ability of cyclodextrin to form an inclusion complex with active principle ingredient (API) or growth factor (GF) for biomedical applications. View Full-Text
Keywords: nanocellulose; β-cyclodextrin; cryogels; films nanocellulose; β-cyclodextrin; cryogels; films
Show Figures

Graphical abstract

MDPI and ACS Style

Michel, B.; Bras, J.; Dufresne, A.; Heggset, E.B.; Syverud, K. Production and Mechanical Characterisation of TEMPO-Oxidised Cellulose Nanofibrils/β-Cyclodextrin Films and Cryogels. Molecules 2020, 25, 2381.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop