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Open AccessArticle

New Cadinane Sesquiterpenes from the Stems of Kadsura heteroclita

1
TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China
2
H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan
*
Authors to whom correspondence should be addressed.
They contributed equally to this work.
Molecules 2019, 24(9), 1664; https://doi.org/10.3390/molecules24091664
Received: 10 March 2019 / Revised: 21 April 2019 / Accepted: 26 April 2019 / Published: 28 April 2019
(This article belongs to the Section Natural Products Chemistry)
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Abstract

As part of our continual efforts to exploit ‘Tujia Ethnomedicine’ for their pharmacophoric functionalities, we herein investigated Kadsura heteroclita collected from a deep Wulin mountain area in northern Hunan province. The current study resulted in the isolation of three new sesquiterpenes: 6α,9α,15-trihydroxycadinan-4-en-3-one (1), (+)-3,11,12-trihydroxycalamenene (2), (–)-3,10,11,12-tetrahydroxy-calamenene (3), along with four known sesquiterpenes (47), and a cytochalasin H (8). Their chemical structures were elucidated by 1D-, and 2D-NMR spectroscopy, and HRESI-MS, CD spectrometry. The antioxidant, and cytotoxic activities of the compounds were evaluated. Compound 8 exhibited a strong antioxidant effect with an IC50 value of 3.67 µM on isolated human polymorphonuclear cells or neutrophils. View Full-Text
Keywords: Kadsura heteroclita; Schisandraceae; sesquiterpenes; antioxidant; Tujia ethnomedicine Kadsura heteroclita; Schisandraceae; sesquiterpenes; antioxidant; Tujia ethnomedicine
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Cao, L.; Shehla, N.; Tasneem, S.; Cao, M.; Sheng, W.; Jian, Y.; Li, B.; Peng, C.; Choudhary, M.I.; Atta-ur-Rahman; Liao, D.-F.; Wang, W. New Cadinane Sesquiterpenes from the Stems of Kadsura heteroclita. Molecules 2019, 24, 1664.

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