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Open AccessArticle

New Cadinane Sesquiterpenes from the Stems of Kadsura heteroclita

TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China
H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan
Authors to whom correspondence should be addressed.
They contributed equally to this work.
Molecules 2019, 24(9), 1664;
Received: 10 March 2019 / Revised: 21 April 2019 / Accepted: 26 April 2019 / Published: 28 April 2019
(This article belongs to the Section Natural Products Chemistry)
PDF [2536 KB, uploaded 28 April 2019]
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As part of our continual efforts to exploit ‘Tujia Ethnomedicine’ for their pharmacophoric functionalities, we herein investigated Kadsura heteroclita collected from a deep Wulin mountain area in northern Hunan province. The current study resulted in the isolation of three new sesquiterpenes: 6α,9α,15-trihydroxycadinan-4-en-3-one (1), (+)-3,11,12-trihydroxycalamenene (2), (–)-3,10,11,12-tetrahydroxy-calamenene (3), along with four known sesquiterpenes (47), and a cytochalasin H (8). Their chemical structures were elucidated by 1D-, and 2D-NMR spectroscopy, and HRESI-MS, CD spectrometry. The antioxidant, and cytotoxic activities of the compounds were evaluated. Compound 8 exhibited a strong antioxidant effect with an IC50 value of 3.67 µM on isolated human polymorphonuclear cells or neutrophils. View Full-Text
Keywords: Kadsura heteroclita; Schisandraceae; sesquiterpenes; antioxidant; Tujia ethnomedicine Kadsura heteroclita; Schisandraceae; sesquiterpenes; antioxidant; Tujia ethnomedicine

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Cao, L.; Shehla, N.; Tasneem, S.; Cao, M.; Sheng, W.; Jian, Y.; Li, B.; Peng, C.; Choudhary, M.I.; Atta-ur-Rahman; Liao, D.-F.; Wang, W. New Cadinane Sesquiterpenes from the Stems of Kadsura heteroclita. Molecules 2019, 24, 1664.

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