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Open AccessArticle

Microwave-Assisted Extraction, Purification, Partial Characterization, and Bioactivity of Polysaccharides from Panax ginseng

1
College of Life Science, Jilin Agricultural University, Changchun 130118, China
2
Institution of Pharmaceutical and Environmental Technology, Jilin Vocational College of Industry and Technology, Jilin 132013, China
3
Engineering Research Center for Agricultural Resources and Comprehensive Utilization of Jilin Provence, Jilin Institute of Chemical Technology, Jilin 132022, China
*
Author to whom correspondence should be addressed.
Academic Editor: Cédric Delattre
Molecules 2019, 24(8), 1605; https://doi.org/10.3390/molecules24081605
Received: 30 March 2019 / Revised: 18 April 2019 / Accepted: 18 April 2019 / Published: 23 April 2019
Polysaccharides are a main active substance in Panax ginseng; however, microwave-assisted extraction used to prepare P. ginseng polysaccharides (MPPG) has rarely been reported, and knowledge of the bactericidal activity of P. ginseng polysaccharides remains low. Thus, this study was designed to investigate the extraction of P. ginseng polysaccharides by using two methods—hot water extraction and microwave-assisted extraction—and compare their chemical composition and structure. In addition, their antibacterial and antioxidant activities were also determined. The data implied that P. ginseng polysaccharides extracted by microwave-assisted extraction possessed a higher extraction yield than hot water extraction (WPPG) under optimized conditions, and the actual yields were 41.6% ± 0.09% and 28.5% ± 1.62%, respectively. Moreover, the preliminary characterization of polysaccharides was identified after purification. The WPPG with the molecular weight (Mw) of 2.07 × 105 Da was composed of Man, Rib, Rha, GalA, Glu, Gal, and Arab, and the typical characteristics of polysaccharides were determined by IR spectra. Compared with WPPG, MPPG had a higher Mw, uronic acid content, and Glu content. More importantly, the antioxidant activity of MPPG was higher than WPPG, which was probably ascribed to its highly Mw and abundant uronic acid content. Besides, both of them exhibited high bactericidal activity. These results demonstrate that microwave-assisted extraction is an effective method for obtaining P. ginseng polysaccharides, and MPPG could be applied as an antioxidant and antibacterial agent. View Full-Text
Keywords: Panax ginseng polysaccharides; microwave-assisted extraction; response surface methodology; structure characterization; bioactivity Panax ginseng polysaccharides; microwave-assisted extraction; response surface methodology; structure characterization; bioactivity
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MDPI and ACS Style

Zhao, J.-L.; Zhang, M.; Zhou, H.-L. Microwave-Assisted Extraction, Purification, Partial Characterization, and Bioactivity of Polysaccharides from Panax ginseng. Molecules 2019, 24, 1605. https://doi.org/10.3390/molecules24081605

AMA Style

Zhao J-L, Zhang M, Zhou H-L. Microwave-Assisted Extraction, Purification, Partial Characterization, and Bioactivity of Polysaccharides from Panax ginseng. Molecules. 2019; 24(8):1605. https://doi.org/10.3390/molecules24081605

Chicago/Turabian Style

Zhao, Jing-Li; Zhang, Meiping; Zhou, Hong-Li. 2019. "Microwave-Assisted Extraction, Purification, Partial Characterization, and Bioactivity of Polysaccharides from Panax ginseng" Molecules 24, no. 8: 1605. https://doi.org/10.3390/molecules24081605

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