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Review

Extraction, Purification, Structural Characteristics, Biological Activities and Pharmacological Applications of Acemannan, a Polysaccharide from Aloe vera: A Review

by 1,2, 3, 1,2, 1,2, 1,2,* and 1,2,*
1
State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China
2
Synergetic Innovation Center for Food Safety and Nutrition, Jiangnan University, Wuxi 214122, China
3
Institute of Agricultural Products Processing, Key Laboratory of Preservation Engineering of Agricultural Products, Ningbo Academy of Agricultural Sciences, Ningbo 315040, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Cédric Delattre
Molecules 2019, 24(8), 1554; https://doi.org/10.3390/molecules24081554
Received: 26 March 2019 / Revised: 11 April 2019 / Accepted: 17 April 2019 / Published: 19 April 2019
Aloe vera is a medicinal plant species of the genus Aloe with a long history of usage around the world. Acemannan, considered one of the main bioactive polysaccharides of Aloe vera, possesses immunoregulation, anti-cancer, anti-oxidation, wound healing and bone proliferation promotion, neuroprotection, and intestinal health promotion activities, among others. In this review, recent advancements in the extraction, purification, structural characteristics and biological activities of acemannan from Aloe vera were summarized. Among these advancements, the structural characteristics of purified polysaccharides were reviewed in detail. Meanwhile, the biological activities of acemannan from Aloe vera determined by in vivo, in vitro and clinical experiments are summarized, and possible mechanisms of these bioactivities were discussed. Moreover, the latest research progress on the use of acemannan in dentistry and wound healing was also summarized in details. The structure-activity relationships of acemannan and its medical applications were discussed. Finally, new perspectives for future research work on acemannan were proposed. In conclusion, this review summarizes the extraction, purification, structural characteristics, biological activities and pharmacological applications of acemannan, and provides information for the industrial production and possible applications in dentistry and wound healing in the future. View Full-Text
Keywords: Aloe vera; polysaccharide; acemannan; biological activity; applications; structure Aloe vera; polysaccharide; acemannan; biological activity; applications; structure
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MDPI and ACS Style

Liu, C.; Cui, Y.; Pi, F.; Cheng, Y.; Guo, Y.; Qian, H. Extraction, Purification, Structural Characteristics, Biological Activities and Pharmacological Applications of Acemannan, a Polysaccharide from Aloe vera: A Review. Molecules 2019, 24, 1554. https://doi.org/10.3390/molecules24081554

AMA Style

Liu C, Cui Y, Pi F, Cheng Y, Guo Y, Qian H. Extraction, Purification, Structural Characteristics, Biological Activities and Pharmacological Applications of Acemannan, a Polysaccharide from Aloe vera: A Review. Molecules. 2019; 24(8):1554. https://doi.org/10.3390/molecules24081554

Chicago/Turabian Style

Liu, Chang, Yan Cui, Fuwei Pi, Yuliang Cheng, Yahui Guo, and He Qian. 2019. "Extraction, Purification, Structural Characteristics, Biological Activities and Pharmacological Applications of Acemannan, a Polysaccharide from Aloe vera: A Review" Molecules 24, no. 8: 1554. https://doi.org/10.3390/molecules24081554

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