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Chemical Constituents of Anacardium occidentale as Inhibitors of Trypanosoma cruzi Sirtuins

1
Instituto Gonçalo Moniz, FIOCRUZ, Salvador, BA 40296-710, Brazil
2
School of Pharmaceutical Sciences, EPGL, University of Geneva, University of Lausanne, CMU, 1, Rue Michel Servet, 1211 Geneva, Switzerland
3
Departmento de Microbiologia, Imunologia e Parasitologia, UNIFESP, São Paulo, SP 04039-032, Brazil
4
Center for Pharmacognostic Research on Panamanian Flora (CIFLORPAN), College of Pharmacy, University of Panama, Panama 0824-00172, Panama
*
Author to whom correspondence should be addressed.
Academic Editor: Thomas J. Schmidt
Molecules 2019, 24(7), 1299; https://doi.org/10.3390/molecules24071299
Received: 23 January 2019 / Revised: 23 February 2019 / Accepted: 26 February 2019 / Published: 3 April 2019
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Abstract

Benznidazole and nifurtimox, the only drugs available for the treatment of Chagas disease, have limited efficacy and have been associated with severe adverse side effects. Thus, there is an urgent need to find new biotargets for the identification of novel bioactive compounds against the parasite and with low toxicity. Silent information regulator 2 (Sir2) enzymes, or sirtuins, have emerged as attractive targets for the development of novel antitrypanosomatid agents. In the present work, we evaluated the inhibitory effect of natural compounds isolated from cashew nut (Anacardium occidentale, L. Anacardiaceae) against the target enzymes TcSir2rp1 and TcSir2rp3 as well as the parasite. Two derivates of cardol (1, 2), cardanol (3, 4), and anacardic acid (5, 6) were investigated. The two anacardic acids (5, 6) inhibited both TcSir2rp1 and TcSir2rp3, while the cardol compound (2) inhibited only TcSir2rp1. The most potent sirtuin inhibitor active against the parasite was the cardol compound (2), with an EC50 value of 12.25 µM, similar to that of benznidazole. Additionally, compounds (1, 4), which were inactive against the sirtuin targets, presented anti-T. cruzi effects. In conclusion, our results showed the potential of Anacardium occidentale compounds for the development of potential sirtuin inhibitors and anti-Trypanosoma cruzi agents. View Full-Text
Keywords: Trypanosoma cruzi; sirtuins; Anacardium occidentale; drug discovery Trypanosoma cruzi; sirtuins; Anacardium occidentale; drug discovery
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Matutino Bastos, T.; Mannochio Russo, H.; Silvio Moretti, N.; Schenkman, S.; Marcourt, L.; Gupta, M.P.; Wolfender, J.-L.; Ferreira Queiroz, E.; Botelho Pereira Soares, M. Chemical Constituents of Anacardium occidentale as Inhibitors of Trypanosoma cruzi Sirtuins. Molecules 2019, 24, 1299.

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