Next Article in Journal
Alkynes as Synthetic Equivalents of Ketones and Aldehydes: A Hidden Entry into Carbonyl Chemistry
Next Article in Special Issue
Recent Advances in Phenylboronic Acid-Based Gels with Potential for Self-Regulated Drug Delivery
Previous Article in Journal
Mechanochemical Synthesis and Characterization of CuInS2/ZnS Nanocrystals
Previous Article in Special Issue
Structure Characterization and Otoprotective Effects of a New Endophytic Exopolysaccharide from Saffron
Article Menu
Issue 6 (March-2) cover image

Export Article

Open AccessReview
Molecules 2019, 24(6), 1035; https://doi.org/10.3390/molecules24061035

Polymeric Co-Delivery Systems in Cancer Treatment: An Overview on Component Drugs’ Dosage Ratio Effect

1
Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115, USA
2
Zanjan Pharmaceutical Nanotechnology Research Center, Zanjan University of Medical Sciences, Zanjan 4513956184, Iran
3
Laboratory of Lipids and Liposomes, Department of Biotechnology, University of Wroclaw, 50-383 Wroclaw, Poland
*
Author to whom correspondence should be addressed.
Received: 21 February 2019 / Revised: 12 March 2019 / Accepted: 13 March 2019 / Published: 15 March 2019
(This article belongs to the Special Issue Smart and Functional Polymers)
Full-Text   |   PDF [2082 KB, uploaded 15 March 2019]   |  

Abstract

Multiple factors are involved in the development of cancers and their effects on survival rate. Many are related to chemo-resistance of tumor cells. Thus, treatment with a single therapeutic agent is often inadequate for successful cancer therapy. Ideally, combination therapy inhibits tumor growth through multiple pathways by enhancing the performance of each individual therapy, often resulting in a synergistic effect. Polymeric nanoparticles prepared from block co-polymers have been a popular platform for co-delivery of combinations of drugs associated with the multiple functional compartments within such nanoparticles. Various polymeric nanoparticles have been applied to achieve enhanced therapeutic efficacy in cancer therapy. However, reported drug ratios used in such systems often vary widely. Thus, the same combination of drugs may result in very different therapeutic outcomes. In this review, we investigated polymeric co-delivery systems used in cancer treatment and the drug combinations used in these systems for synergistic anti-cancer effect. Development of polymeric co-delivery systems for a maximized therapeutic effect requires a deeper understanding of the optimal ratio among therapeutic agents and the natural heterogenicity of tumors. View Full-Text
Keywords: polymeric nanoparticles; stimuli-sensitive polymers; co-delivery systems; synergistic effect; nucleic acid delivery; chemotherapy polymeric nanoparticles; stimuli-sensitive polymers; co-delivery systems; synergistic effect; nucleic acid delivery; chemotherapy
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Pan, J.; Rostamizadeh, K.; Filipczak, N.; Torchilin, V.P. Polymeric Co-Delivery Systems in Cancer Treatment: An Overview on Component Drugs’ Dosage Ratio Effect. Molecules 2019, 24, 1035.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top