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Recent Advances in Phenylboronic Acid-Based Gels with Potential for Self-Regulated Drug Delivery

Department of Orthopedics, Hallym University, 1 Hallymdaehak-gil, Chuncheon, Gangwon-do 200-702, Korea
Laboratory of Building Energy-Saving Technology Engineering, College of Material Science and Engineering, Jilin Jianzhu University, Changchun 130118, China
Authors to whom correspondence should be addressed.
Academic Editors: Jianxun Ding, Yang Li and Mingqiang Li
Molecules 2019, 24(6), 1089;
Received: 2 February 2019 / Revised: 14 March 2019 / Accepted: 15 March 2019 / Published: 19 March 2019
(This article belongs to the Special Issue Smart and Functional Polymers)
PDF [7009 KB, uploaded 19 March 2019]


Glucose-sensitive drug platforms are highly attractive in the field of self-regulated drug delivery. Drug carriers based on boronic acid (BA), especially phenylboronic acid (PBA), have been designed for glucose-sensitive self-regulated insulin delivery. The PBA-functionalized gels have attracted more interest in recent years. The cross-linked three-dimensional (3D) structure endows the glucose-sensitive gels with great physicochemical properties. The PBA-based platforms with cross-linked structures have found promising applications in self-regulated drug delivery systems. This article summarizes some recent attempts at the developments of PBA-mediated glucose-sensitive gels for self-regulated drug delivery. The PBA-based glucose-sensitive gels, including hydrogels, microgels, and nanogels, are expected to significantly promote the development of smart self-regulated drug delivery systems for diabetes therapy. View Full-Text
Keywords: phenylboronic acid; gel; glucose sensitivity; drug delivery; diabetes therapy phenylboronic acid; gel; glucose sensitivity; drug delivery; diabetes therapy

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Wang, C.; Lin, B.; Zhu, H.; Bi, F.; Xiao, S.; Wang, L.; Gai, G.; Zhao, L. Recent Advances in Phenylboronic Acid-Based Gels with Potential for Self-Regulated Drug Delivery. Molecules 2019, 24, 1089.

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