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Molecules 2019, 24(6), 1033;

Application of Antimicrobial Nanoparticles in Dentistry

Shandong Provincial Key Laboratory of Oral Tissue Regeneration, School of Stomatology, Shandong University, Jinan 250012, China
Department of Periodontology, School of Stomatology, Shandong University, Jinan 250012, China
Author to whom correspondence should be addressed.
Academic Editor: Franco Dosio
Received: 20 February 2019 / Revised: 3 March 2019 / Accepted: 8 March 2019 / Published: 15 March 2019
(This article belongs to the Special Issue Frontiers of Antimicrobial Nanoparticles)
Full-Text   |   PDF [532 KB, uploaded 15 March 2019]   |  


Oral cavity incessantly encounters a plethora of microorganisms. Plaque biofilm—a major cause of caries, periodontitis and other dental diseases—is a complex community of bacteria or fungi that causes infection by protecting pathogenic microorganisms from external drug agents and escaping the host defense mechanisms. Antimicrobial nanoparticles are promising because of several advantages such as ultra-small sizes, large surface-area-to-mass ratio and special physical and chemical properties. To better summarize explorations of antimicrobial nanoparticles and provide directions for future studies, we present the following critical review. The keywords “nanoparticle,” “anti-infective or antibacterial or antimicrobial” and “dentistry” were retrieved from Pubmed, Scopus, Embase and Web of Science databases in the last five years. A total of 172 articles met the requirements were included and discussed in this review. The results show that superior antibacterial properties of nanoparticle biomaterials bring broad prospects in the oral field. This review presents the development, applications and underneath mechanisms of antibacterial nanoparticles in dentistry including restorative dentistry, endodontics, implantology, orthodontics, dental prostheses and periodontal field. View Full-Text
Keywords: application; antimicrobial; nanoparticles; dentistry application; antimicrobial; nanoparticles; dentistry

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Song, W.; Ge, S. Application of Antimicrobial Nanoparticles in Dentistry. Molecules 2019, 24, 1033.

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