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Open AccessReview

Dietary Phytochemicals Targeting Cancer Stem Cells

1
Clinic of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, 03601 Bratislava, Slovakia
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Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, 03601 Bratislava, Slovakia
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Department of Obstetrics and Gynecology Faculty Hospital Nitra Constantine the Philosopher University, 949 01 Nitra, Slovakia
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Department of Physiology and Biophysics, Weill Cornell Medicine-Qatar, Education City, Qatar Foundation, P.O. Box 24144, Doha 24144, Qatar
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Institute for Health and Sport, Victoria University, Melbourne, VIC 3011, Australia
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Department of Immunology and School of Medicine, Keimyung University, Dalseo-Gu, 426 01 Daegu, Korea
*
Authors to whom correspondence should be addressed.
Molecules 2019, 24(5), 899; https://doi.org/10.3390/molecules24050899
Received: 8 February 2019 / Revised: 25 February 2019 / Accepted: 28 February 2019 / Published: 4 March 2019
(This article belongs to the Special Issue Antitumoral Properties of Natural Products)
There is an increasing awareness of the importance of a diet rich in fruits and vegetables for human health. Cancer stem cells (CSCs) are characterized as a subpopulation of cancer cells with aberrant regulation of self-renewal, proliferation or apoptosis leading to cancer progression, invasiveness, metastasis formation, and therapy resistance. Anticancer effects of phytochemicals are also directed to target CSCs. Here we provide a comprehensive review of dietary phytochemicals targeting CSCs. Moreover, we evaluate and summarize studies dealing with effects of dietary phytochemicals on CSCs of various malignancies in preclinical and clinical research. Dietary phytochemicals have a significant impact on CSCs which may be applied in cancer prevention and treatment. However, anticancer effects of plant derived compounds have not yet been fully investigated in clinical research. View Full-Text
Keywords: cancer stem cells; phytochemicals; plant-derived foods; fruit; vegetable; cell signaling cancer stem cells; phytochemicals; plant-derived foods; fruit; vegetable; cell signaling
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Liskova, A.; Kubatka, P.; Samec, M.; Zubor, P.; Mlyncek, M.; Bielik, T.; Samuel, S.M.; Zulli, A.; Kwon, T.K.; Büsselberg, D. Dietary Phytochemicals Targeting Cancer Stem Cells. Molecules 2019, 24, 899.

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