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Article

1-O-Hexyl-2,3,5-Trimethylhydroquinone Ameliorates l-DOPA-Induced Cytotoxicity in PC12 Cells

1
Department of Pharmacy and Research Center for Bioresource and Health, College of Pharmacy, Chungbuk National University, 194-21, Osongsaengmyung 1-ro, Osong, Heungduk-gu, Cheongju 28160, Korea
2
Department of Veterinary Medicine, College of Veterinary Medicine, Chungbuk National University, 1, Chungdae-ro, Seowon-gu, Cheongju 28644, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Jia Zhou
Molecules 2019, 24(5), 867; https://doi.org/10.3390/molecules24050867
Received: 14 February 2019 / Revised: 21 February 2019 / Accepted: 22 February 2019 / Published: 1 March 2019
(This article belongs to the Special Issue Neuroprotective Agents)
1-O-Hexyl-2,3,5-trimethylhydroquinone (HTHQ) has previously been found to have effective anti-oxidant and anti-lipid-peroxidative activity. We aimed to elucidate whether HTHQ can prevent dopaminergic neuronal cell death by investigating the effect on l-DOPA-induced cytotoxicity in PC12 cells. HTHQ protected from both l-DOPA-induced cell death and superoxide dismutase activity reduction. When assessing the effect of HTHQ on oxidative stress-related signaling pathways, HTHQ inhibited l-DOPA-induced phosphorylation of sustained extracellular signal-regulated kinases (ERK1/2), p38 mitogen-activated protein kinase (MAPK), and c-Jun N-terminal kinase (JNK1/2). HTHQ also normalized l-DOPA-reduced Bcl-2-associated death protein (Bad) phosphorylation and Bcl-2-associated X protein (Bax) expression, promoting cell survival. Taken together, HTHQ exhibits protective effects against l-DOPA-induced cell death through modulation of the ERK1/2-p38MAPK-JNK1/2-Bad-Bax signaling pathway in PC12 cells. These results suggest that HTHQ may show ameliorative effects against oxidative stress-induced dopaminergic neuronal cell death, although further studies in animal models of Parkinson’s disease are required to confirm this. View Full-Text
Keywords: 1-O-hexyl-2,3,5-trimethylhydroquinone; l-DOPA-induced cytotoxicity; superoxide dismutase; ERK1/2; JNK1/2; PC12 cells 1-O-hexyl-2,3,5-trimethylhydroquinone; l-DOPA-induced cytotoxicity; superoxide dismutase; ERK1/2; JNK1/2; PC12 cells
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MDPI and ACS Style

Park, H.J.; Kang, J.K.; Lee, M.K. 1-O-Hexyl-2,3,5-Trimethylhydroquinone Ameliorates l-DOPA-Induced Cytotoxicity in PC12 Cells. Molecules 2019, 24, 867. https://doi.org/10.3390/molecules24050867

AMA Style

Park HJ, Kang JK, Lee MK. 1-O-Hexyl-2,3,5-Trimethylhydroquinone Ameliorates l-DOPA-Induced Cytotoxicity in PC12 Cells. Molecules. 2019; 24(5):867. https://doi.org/10.3390/molecules24050867

Chicago/Turabian Style

Park, Hyun J., Jong K. Kang, and Myung K. Lee. 2019. "1-O-Hexyl-2,3,5-Trimethylhydroquinone Ameliorates l-DOPA-Induced Cytotoxicity in PC12 Cells" Molecules 24, no. 5: 867. https://doi.org/10.3390/molecules24050867

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